Description
| Product Name: | Human SULT2A1 Recombinant Protein |
| Product Code: | RPPB2297 |
| Size: | 20µg |
| Species: | Human |
| Target: | SULT2A1 |
| Synonyms: | Sulfotransferase family cytosolic 2A dehydroepiandrosterone (DHEA)-preferring member 1, DHEA-ST, STD, HST, ST2, ST2A1, ST2A3, Alcohol/hydroxysteroid sulfotransferase, bile-salt sulfotranasferase 2A1, EC 2.8.2.14. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | SULT2A1 protein solution (1mg/1ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSDDFLWFEG IAFPTMGFRS ETLRKVRDEF VIRDEDVIIL TYPKSGTNWL AEILCLMHSK GDAKWIQSVP IWERSPWVES EIGYTALSET ESPRLFSSHL PIQLFPKSFF SSKAKVIYLM RNPRDVLVSG YFFWKNMKFI KKPKSWEEYF EWFCQGTVLY GSWFDHIHGW MPMREEKNFL LLSYEELKQD TGRTIEKICQ FLGKTLEPEE LNLILKNSSF QSMKENKMSN YSLLSVDYVV DKAQLLRKGV SGDWKNHFTV AQAEDFDKLF QEKMADLPRE LFPWE |
SULT2A1 is a member fo the sulfotransferase family. SULT2A1 is primarily expressed in liver and adrenal tissues, and to a lesser extent in kidney. SULT2A1 catalyzes the 3'-phosphoadenosine 5'-phosphosulfate-dependent sulfation of an extensive selection of steroids in human liver and adrenal tissues, and in addition is responsible for a larg number of the sulfation of bile acids in human liver.
SULT2A1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 305 amino acids (1-285a.a) and having a molecular mass of 35.9kDa.SULT2A1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SULT2A1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Belongs to the sulfotransferase 1 family. |
| UniProt Protein Details: | Protein type:EC 2.8.2.14; Transferase Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: cytosol Molecular Function:sulfotransferase activity; protein binding; bile-salt sulfotransferase activity Biological Process: steroid metabolic process; xenobiotic metabolic process; bile acid catabolic process; sulfation; digestion; cellular lipid metabolic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| NCBI Summary: | This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q06520 |
| NCBI GenInfo Identifier: | 1711591 |
| NCBI Gene ID: | 6822 |
| NCBI Accession: | Q06520.3 |
| UniProt Related Accession: | Q06520 |
| Molecular Weight: | 285 |
| NCBI Full Name: | Bile salt sulfotransferase |
| NCBI Synonym Full Names: | sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 |
| NCBI Official Symbol: | SULT2A1�� |
| NCBI Official Synonym Symbols: | HST; ST2; STD; hSTa; DHEAS; ST2A1; ST2A3; DHEA-ST�� |
| NCBI Protein Information: | bile salt sulfotransferase; bile-salt sulfotranasferase 2A1; alcohol/hydroxysteroid sulfotransferase |
| UniProt Protein Name: | Bile salt sulfotransferase |
| UniProt Synonym Protein Names: | Dehydroepiandrosterone sulfotransferase; DHEA-ST; Hydroxysteroid Sulfotransferase; HST; ST2; ST2A3; Sulfotransferase 2A1; ST2A1 |
| Protein Family: | Bile salt sulfotransferase |
| UniProt Gene Name: | SULT2A1�� |
| UniProt Entry Name: | ST2A1_HUMAN |
