Description
| Product Name: | Human SULT1A2 Recombinant Protein |
| Product Code: | RPPB2292 |
| Size: | 20µg |
| Species: | Human |
| Target: | SULT1A2 |
| Synonyms: | Sulfotransferase 1A2, ST1A2, Aryl sulfotransferase 2, Phenol sulfotransferase 2, Phenol-sulfating phenol sulfotransferase 2, P-PST 2, SULT1A2, STP2, HAST4, TSPST2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SULT1A2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MELIQDISRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLISTYPKSG TTWVSQILDM IYQGGDLEKC HRAPIFMRVP FLEFKVPGIP SGMETLKNTP APRLLKTHLP LALLPQTLLD QKVKVVYVAR NAKDVAVSYY HFYHMAKVYP HPGTWESFLE KFMAGEVSYG SWYQHVQEWW ELSRTHPVLY LFYEDMKENP KREIQKILEF VGRSLPEETV DLMVEHTSFK EMKKNPMTNY TTVRREFMDH SISPFMRKGM AGDWKTTFTV AQNERFDADY AEKMAGCSLS FRSEL |
Sulfotransferase 1A2 (SULT1A2) belongs to the sulfotransferase family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. SULT1A2 mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and might thus participate as a modulating factor of cancer risk.
SULT1A2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 315 amino acids (1-295 a.a.) and having a molecular mass of 36.4kDa.SULT1A2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SULT1A2: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. Belongs to the sulfotransferase 1 family. |
| UniProt Protein Details: | Protein type:EC 2.8.2.1; Energy Metabolism - sulfur; Transferase Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: cytosol Molecular Function:aryl sulfotransferase activity; flavonol 3-sulfotransferase activity; protein binding; sulfotransferase activity Biological Process: 3'-phosphoadenosine 5'-phosphosulfate metabolic process; amine biosynthetic process; ethanol catabolic process; phenol metabolic process; sulfation; xenobiotic metabolic process |
| NCBI Summary: | Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P50226 |
| NCBI GenInfo Identifier: | 288558827 |
| NCBI Gene ID: | 6799 |
| NCBI Accession: | P50226.2 |
| UniProt Secondary Accession: | P50226,P78393, Q14CJ7, A9QY25, |
| UniProt Related Accession: | P50226 |
| Molecular Weight: | 34kDa |
| NCBI Full Name: | Sulfotransferase 1A2 |
| NCBI Synonym Full Names: | sulfotransferase family 1A member 2 |
| NCBI Official Symbol: | SULT1A2�� |
| NCBI Official Synonym Symbols: | STP2; HAST4; P-PST; ST1A2; TSPST2�� |
| NCBI Protein Information: | sulfotransferase 1A2 |
| UniProt Protein Name: | Sulfotransferase 1A2 |
| UniProt Synonym Protein Names: | Aryl sulfotransferase 2; Phenol sulfotransferase 2; Phenol-sulfating phenol sulfotransferase 2; P-PST 2 |
| Protein Family: | Sulfotransferase |
| UniProt Gene Name: | SULT1A2�� |
