Description
| Product Name: | Human STMN2 Recombinant Protein |
| Product Code: | RPPB4850 |
| Size: | 10µg |
| Species: | Human |
| Target: | STMN2 |
| Synonyms: | SCG10, STMB2, SCGN10, AI159727, STMN-2, Stathmin-2, Superior cervical ganglion-10 protein, Protein SCG10, STMN2, SGC10, stathmin-like 2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The STMN2 protein solution contains 50mM Tris-HCl, pH-7.5 and 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MDMEVKQINK RASGQAFELI LKPPSPISEA PRTLASPKKK DLSLEEIQKK LEAAEERRKS QEAQVLKQLA EKREHEREVL QKALEENNNF SKMAEEKLIL KMEQIKENRE ANLAAIIERL QEKERHAAEV RRNKELQVEL SG |
STMN2 is a neuronal growth-associated protein which shares a majority of its amino acid sequence with the phosphoprotein stathmin. STMN2 is involved in neuronal differentiation and in modulating membrane interaction with the cytoskeleton through neurite outgrowth. STMN2 is necessary for maintaining the anchorage-independent growth state of beta-catenin/TCF-activated hepatoma cells. SCG10 is a novel indicator of osteogenesis and osteoblast that takes part in the regulation of the adipocyte/osteoblast balance. STMN2 plays a role as an effector downstream of Rnd1 to regulate axon extensions by modulating microtubule organization.
Recombinant Human Stathmin Like-2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 142 amino acids (39-179 a.a) and having a molecular mass of 16.4 kDa. STMN2 is purified by conventional chromatography techniques.
| UniProt Protein Function: | STMN2: a cytoskeletal protein that may play a role in neuronal differentiation, and in modulating membrane interaction with the cytoskeleton during neurite outgrowth. Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. Neuron specific. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 8q21.13 Cellular Component: cell soma; cytoplasm; growth cone; lamellipodium; neuron projection; perinuclear region of cytoplasm Molecular Function:calcium-dependent protein binding; protein binding; tubulin binding Biological Process: negative regulation of microtubule depolymerization; negative regulation of microtubule polymerization; positive regulation of microtubule depolymerization |
| NCBI Summary: | This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q93045 |
| NCBI GenInfo Identifier: | 51704330 |
| NCBI Gene ID: | 11075 |
| NCBI Accession: | Q93045.3 |
| UniProt Secondary Accession: | Q93045,O14952, Q6PK68, A8K9M2, G3V110, |
| UniProt Related Accession: | Q93045 |
| Molecular Weight: | 21,802 Da |
| NCBI Full Name: | Stathmin-2 |
| NCBI Synonym Full Names: | stathmin 2 |
| NCBI Official Symbol: | STMN2�� |
| NCBI Official Synonym Symbols: | SCG10; SCGN10�� |
| NCBI Protein Information: | stathmin-2 |
| UniProt Protein Name: | Stathmin-2 |
| UniProt Synonym Protein Names: | Superior cervical ganglion-10 protein; Protein SCG10 |
| Protein Family: | Stathmin |
| UniProt Gene Name: | STMN2�� |
| UniProt Entry Name: | STMN2_HUMAN |
