Description
| Product Name: | Human SSSCA1 Recombinant Protein |
| Product Code: | RPPB4834 |
| Size: | 10µg |
| Species: | Human |
| Target: | SSSCA1 |
| Synonyms: | Sjogren Syndrome/Scleroderma Autoantigen 1, Sjogren'SSyndrome/Scleroderma Autoantigen 1, Autoantigen P27, Centromeric Autoantigen(27kD), p27, Sjoegren Syndrome/Scleroderma Autoantigen 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | SSSCA1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMALNGAE VDDFSWEPPT EAETKVLQAR RERQDRISRL MGDYLLRGYRMLGETCADCG TILLQDKQRK IYCVACQELD SDVDKDNPAL NAQAALSQAR EHQLASASEL PLGSRPAPQPPVPRPEHCEG AAAGLKAAQG PPAPAVPPNT DVMACTQTAL LQKLTWASAE LGSSTSLETS IQLCGLIRAC AEALRSLQQL QH |
Sjogrensyndrome/scleroderma autoantigen 1, SSSCA1 is involved in mitosis. SSSCA1 is acentromere-associated protein which can induce anti-centromereantibodies. In addition SSSCA1 is recognized by a subset of anti-centromere antibodies from patients with scleroderma and Sjogren'ssyndrome.
SSSCA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 222 amino acids (1-199aa) and having a molecular mass of 23.9kDa. SSSCA1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SSSCA1: Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q13.1 Molecular Function:protein binding |
| NCBI Summary: | This antigen is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjogren's syndrome. Subcellular localization has not yet been established. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60232 |
| NCBI GenInfo Identifier: | 5902701 |
| NCBI Gene ID: | 10534 |
| NCBI Accession: | O60232.1 |
| UniProt Related Accession: | O60232 |
| Molecular Weight: | 21,474 Da |
| NCBI Full Name: | Sjoegren syndrome/scleroderma autoantigen 1 |
| NCBI Synonym Full Names: | Sjogren syndrome/scleroderma autoantigen 1 |
| NCBI Official Symbol: | SSSCA1�� |
| NCBI Official Synonym Symbols: | p27�� |
| NCBI Protein Information: | Sjoegren syndrome/scleroderma autoantigen 1 |
| UniProt Protein Name: | Sjoegren syndrome/scleroderma autoantigen 1 |
| UniProt Synonym Protein Names: | Autoantigen p27 |
| Protein Family: | Sjoegren syndrome/scleroderma autoantigen |
| UniProt Gene Name: | SSSCA1�� |
| UniProt Entry Name: | SSA27_HUMAN |
