Description
| Product Name: | Human SSR4 Recombinant Protein |
| Product Code: | RPPB4833 |
| Size: | 20µg |
| Species: | Human |
| Target: | SSR4 |
| Synonyms: | TRAPD, Translocon-associated protein subunit delta, TRAP-delta, Signal sequence receptor subunit delta SSR-delta. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | SSR4 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSEACLEPQ ITPSYYTTSD AVISTETVFI VEISLTCKNR VQNMALYADV GGKQFPVTRG QDVGRYQVSW SLDHKSAHAG TYEVRFFDEE SYSLLRKAQR NNEDISIIPP LFTVSVDHRG TWNG |
SSR4 is a member of the TRAP-delta family. SSR4 is the delta subunit of the translocon-associated protein complex that participates in translocating proteins through the endoplasmic reticulum membrane. SSR4 positioned in the Xq28 region and organized in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene. Both genes are motivated by a CpG-embedded bidirectional promoter.
SSR4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 144 amino acids (24-144 a.a.) and having a molecular mass of 16.1kDa.SSR4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SSR4: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Belongs to the TRAP-delta family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xq28 Disease: Congenital Disorder Of Glycosylation, Type Iy |
| NCBI Summary: | This gene encodes the delta subunit of the translocon-associated protein complex which is involved in translocating proteins across the endoplasmic reticulum membrane. The encoded protein is located in the Xq28 region and is arranged in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene and both genes are driven by a CpG-embedded bidirectional promoter. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011] |
| UniProt Code: | P51571 |
| NCBI GenInfo Identifier: | 1711550 |
| NCBI Gene ID: | 6748 |
| NCBI Accession: | P51571.1 |
| UniProt Secondary Accession: | P51571,Q53XY1, A8K378, |
| UniProt Related Accession: | P51571 |
| Molecular Weight: | 18,999 Da |
| NCBI Full Name: | Translocon-associated protein subunit delta |
| NCBI Synonym Full Names: | signal sequence receptor subunit 4 |
| NCBI Official Symbol: | SSR4�� |
| NCBI Official Synonym Symbols: | CDG1Y; TRAPD�� |
| NCBI Protein Information: | translocon-associated protein subunit delta |
| UniProt Protein Name: | Translocon-associated protein subunit delta |
| UniProt Synonym Protein Names: | Signal sequence receptor subunit delta; SSR-delta |
| Protein Family: | SWI/SNF and RSC complexes |
| UniProt Gene Name: | SSR4�� |
| UniProt Entry Name: | SSRD_HUMAN |
