Description
| Product Name: | Human SSR2 Recombinant Protein |
| Product Code: | RPPB4832 |
| Size: | 20µg |
| Species: | Human |
| Target: | SSR2 |
| Synonyms: | HSD25, TLAP, TRAP-BETA, TRAPB, Translocon-associated protein subunit beta, Signal sequence receptor subunit beta, SSR-beta. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SSR2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSEEGARLL ASKSLLNRYA VEGRDLTLQY NIYNVGSSAA LDVELSDDSF PPEDFGIVSG MLNVKWDRIA PASNVSHTVV LRPLKAGYFN FTSATITYLA QEDGPVVIGS TSAPGQGGIL AQREFDRRFS PHFLD |
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum membrane receptor related with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. Diseases correlated with SSR2 include calcaneonavicular coalition, and osteosarcoma, and among its related super-pathways are Viral mRNA Translation and Generic Transcription Pathway.
SSR2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids (18-149a.a) and having a molecular mass of 16.8kDa. SSR2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SSR2: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Belongs to the TRAP-beta family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 1q21-q23Cellular Component: endoplasmic reticulumBiological Process: cotranslational protein targeting to membrane |
| UniProt Protein Details: | |
| NCBI Summary: | The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P43308 |
| NCBI GenInfo Identifier: | 1174451 |
| NCBI Gene ID: | 6746 |
| NCBI Accession: | P43308.1 |
| UniProt Secondary Accession: | P43308,Q53HI0, Q5VY95, Q5VY96, Q6IB31, Q9BWE4, B2R9K9 D3DVA7 |
| UniProt Related Accession: | P43308 |
| Molecular Weight: | 20,135 Da |
| NCBI Full Name: | Translocon-associated protein subunit beta |
| NCBI Synonym Full Names: | signal sequence receptor subunit 2 |
| NCBI Official Symbol: | SSR2�� |
| NCBI Official Synonym Symbols: | TLAP; HSD25; TRAPB; TRAP-BETA�� |
| NCBI Protein Information: | translocon-associated protein subunit beta |
| UniProt Protein Name: | Translocon-associated protein subunit beta |
| UniProt Synonym Protein Names: | Signal sequence receptor subunit beta; SSR-beta |
| Protein Family: | SWI/SNF and RSC complexes |
| UniProt Gene Name: | SSR2�� |
| UniProt Entry Name: | SSRB_HUMAN |
