Description
| Product Name: | Human SSR1 Recombinant Protein |
| Product Code: | RPPB4831 |
| Size: | 10µg |
| Species: | Human |
| Target: | SSR1 |
| Synonyms: | Signal Sequence Receptor Alpha, Translocon-AssociatedProtein Alpha, SSR Alpha Subunit, TRAP-alpha, TRAPA. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | SSR1 protein solution (0.25mg/ml) containing 20mMTris-HCl buffer (pH8.0), 0.1M NaCl, 1mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSRGGPRGL LAVAQDLTED EETVEDSIIE DEDDEAEVEE DEPTDLVEDKEEEDVSGEPE ASPSADTTIL FVKGEDFPAN NIVKFLVGFT NKGTEDFIVE SLDASFRYPQ DYQFYIQNFTALPLNTVVPP QRQATFEYSF IPAEPMGGRP FGLVINLNYK DLNGNVFQDA VFNQTVTVIE REDGLDGET |
SSR is a glycosylated endoplasmic reticulum (ER) membrane receptor involved in protein translocation across the ER membrane. SSR is formed of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. SSR gene creates a number of mRNA species due to complex alternative polyadenylation. SSR is unique since it exploits arrays of polyA signal sequences which are mostly non-canonical.
SSR1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain topological domain containing 209 aminoacids (22-207 a.a) and having a molecular mass of 23.1kDa. SSR1 is fused to a 23 aminoacid His-tag at N-terminus & purified by proprietary chromatographictechniques.
| UniProt Protein Function: | SSR1: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. Belongs to the TRAP-alpha family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p24.3 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane Molecular Function:protein binding Biological Process: cotranslational protein targeting to membrane; positive regulation of cell proliferation |
| NCBI Summary: | The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014] |
| UniProt Code: | P43307 |
| NCBI GenInfo Identifier: | 22261821 |
| NCBI Gene ID: | 6745 |
| NCBI Accession: | P43307.3 |
| UniProt Secondary Accession: | P43307,Q53GX2, Q53H19, Q5TAM3, Q6IB43, Q8NBH9, Q96IA2 Q9TNQ8, Q9UN49, A8K685, |
| UniProt Related Accession: | P43307 |
| Molecular Weight: | 29,373 Da |
| NCBI Full Name: | Translocon-associated protein subunit alpha |
| NCBI Synonym Full Names: | signal sequence receptor subunit 1 |
| NCBI Official Symbol: | SSR1�� |
| NCBI Official Synonym Symbols: | TRAPA�� |
| NCBI Protein Information: | translocon-associated protein subunit alpha |
| UniProt Protein Name: | Translocon-associated protein subunit alpha |
| UniProt Synonym Protein Names: | Signal sequence receptor subunit alpha; SSR-alpha |
| Protein Family: | SWI/SNF and RSC complexes |
| UniProt Gene Name: | SSR1�� |
| UniProt Entry Name: | SSRA_HUMAN |
