Description
| Product Name: | Human SRI Recombinant Protein |
| Product Code: | RPPB4825 |
| Size: | 20µg |
| Species: | Human |
| Target: | SRI |
| Synonyms: | Sorcin, 22 kDa protein, CP-22, CP22, V19, SRI, SCN, FLJ26259. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SRI solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.2M NaCl, 1mM DTT and 0.1mM PMSF. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAYPGHP GAGGGYYPGG YGGAPGGPAF PGQTQDPLYG YFAAVAGQDG QIDADELQRC LTQSGIAGGY KPFNLETCRL MVSMLDRDMS GTMGFNEFKE LWAVLNGWRQ HFISFDTDRS GTVDPQELQK ALTTMGFRLS PQAVNSIAKR YSTNGKITFD DYIACCVKLR ALTDSFRRRD TAQQGVVNFP YDDFIQCVMS V |
Sorcin (SRI) which is a 22kDa calcium-binding protein was originally identified in multidrug-resistant cells. Sorcin, which modulates excitation-contraction coupling in the heart, contributes to calcium homeostasis in the heart sarcoplasmic reticulum.
SRI Human Recombinant fused with a�23 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�221 amino acids (1-198 a.a.) and having a molecular mass of 24.1kDa. The SRI is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SRI: Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 7q21.1 Cellular Component: nucleoplasm; endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; membrane; mitochondrion; sarcoplasmic reticulum; T-tubule; cytoplasm; nerve terminal; cytosol; Z disc Molecular Function:protein binding; protease binding; protein heterodimerization activity; calcium channel regulator activity; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding; receptor binding Biological Process: regulation of action potential; cytoplasmic sequestering of transcription factor; muscle development; negative regulation of heart rate; heart development; regulation of striated muscle contraction; regulation of calcium ion transport; proteolysis; signal transduction; regulation of heart contraction; transport; calcium ion transport; positive regulation of release of sequestered calcium ion into cytosol; intracellular sequestering of iron ion |
| NCBI Summary: | This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P30626 |
| NCBI GenInfo Identifier: | 267021 |
| NCBI Gene ID: | 6717 |
| NCBI Accession: | P30626.1 |
| UniProt Secondary Accession: | P30626,A8MTH6, B4DKK2, D6W5Q0, |
| UniProt Related Accession: | P30626 |
| Molecular Weight: | 198 |
| NCBI Full Name: | Sorcin |
| NCBI Synonym Full Names: | sorcin |
| NCBI Official Symbol: | SRI�� |
| NCBI Official Synonym Symbols: | SCN; V19; CP22; CP-22�� |
| NCBI Protein Information: | sorcin; H_RG167B05.1; 22 kDa protein; calcium binding protein amplified in mutlidrug-resistant cells |
| UniProt Protein Name: | Sorcin |
| UniProt Synonym Protein Names: | 22 kDa protein; CP-22; CP22; V19 |
| UniProt Gene Name: | SRI�� |
| UniProt Entry Name: | SORCN_HUMAN |
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