Description
| Product Name: | Human SNRPD3 Recombinant Protein |
| Product Code: | RPPB4758 |
| Size: | 10µg |
| Species: | Human |
| Target: | SNRPD3 |
| Synonyms: | Small nuclear ribonucleoprotein D3 polypeptide 18kDa, Sm-D3, snRNP core protein D3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SNRPD3 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.5M NaCl, 2mM DTT, 0.1mM PMSF and 40% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSIGVPIKVL HEAEGHIVTC ETNTGEVYRG KLIEAEDNMN CQMSNITVTY RDGRVAQLEQ VYIRGSKIRF LILPDMLKNA PMLKSMKNKN QGSGAGRGKA AILKAQVAAR GRGRGMGRGN IFQKRR |
SNRPD3 is a small nuclear ribonucleoprotein (snRNPs) that contains the spliceosome in eukaryotes. SNRPD3 is essential for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing happens in this locus and two transcript variants encoding the same protein were branded.
SNRPD3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 146 amino acids (1-126) and having a molecular mass of 16.0 kDa.The SNRPD3 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | snRNP D3: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. Belongs to the snRNP core protein family. |
| UniProt Protein Details: | Protein type:RNA splicing; Spliceosome; RNA-binding Chromosomal Location of Human Ortholog: 22q11.23 Cellular Component: cytoplasm; cytosol; nucleoplasm; small nuclear ribonucleoprotein complex; snRNP U1; snRNP U2; snRNP U5; spliceosome; telomerase holoenzyme complex; U12-dependent spliceosome Molecular Function:enzyme binding; protein binding Biological Process: histone mRNA metabolic process; nuclear import; nuclear mRNA splicing, via spliceosome; protein amino acid methylation; RNA splicing; spliceosomal snRNP biogenesis; spliceosome assembly; termination of RNA polymerase II transcription |
| NCBI Summary: | This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | P62318 |
| NCBI GenInfo Identifier: | 51338667 |
| NCBI Gene ID: | 6634 |
| NCBI Accession: | P62318.1 |
| UniProt Secondary Accession: | P62318,P43331, B4DJP7, B5BU13, |
| UniProt Related Accession: | P62318 |
| Molecular Weight: | 13,292 Da |
| NCBI Full Name: | Small nuclear ribonucleoprotein Sm D3 |
| NCBI Synonym Full Names: | small nuclear ribonucleoprotein D3 polypeptide |
| NCBI Official Symbol: | SNRPD3�� |
| NCBI Official Synonym Symbols: | SMD3; Sm-D3�� |
| NCBI Protein Information: | small nuclear ribonucleoprotein Sm D3 |
| UniProt Protein Name: | Small nuclear ribonucleoprotein Sm D3 |
| UniProt Synonym Protein Names: | snRNP core protein D3 |
| UniProt Gene Name: | SNRPD3�� |
| UniProt Entry Name: | SMD3_HUMAN |
