Description
| Product Name: | Human SNRPB2 Recombinant Protein |
| Product Code: | RPPB4751 |
| Size: | 10µg |
| Species: | Human |
| Target: | SNRPB2 |
| Synonyms: | Small nuclear ribonucleoprotein polypeptide B2, Msl1, U2 snRNP B'', U2 small nuclear ribonucleoprotein B'', MGC24807, MGC45309. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SNRPB2 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 40% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MDIRPNHTIY INNMNDKIKK EELKRSLYAL FSQFGHVVDI VALKTMKMRG QAFVIFKELG SSTNALRQLQ GFPFYGKPMR IQYAKTDSDI ISKMRGTFAD KEKKKEKKKA KTVEQTATTT NKKPGQGTPN SANTQGNSTP NPQVPDYPPN YILFLNNLPE� ETNEMMLSML FNQFPGFKEV RLVPGRHDIA FVEFENDGQA GAARDALQGF KITPSHAMKI TYAKK |
SNRPB2 is a member of the RRM U1 A/B family. SNRPB2 links with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A. SNRPB2 has a part in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus often identify epitopes on the encoded protein. A pair of transcript variants encoding the same protein were identified for this gene.
SNRPB2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 245 amino acids (1-225a.a.) and having a molecular mass of 27.6kDa. The SNRPB2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | snRNP B2: a small nuclear ribonucleoprotein. Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the A' protein. |
| UniProt Protein Details: | Protein type:RNA processing; RNA splicing; Spliceosome; RNA-binding Chromosomal Location of Human Ortholog: 20p12.1 Cellular Component: nucleolus; nucleoplasm; snRNP U2; spliceosome Molecular Function:protein binding Biological Process: nuclear mRNA splicing, via spliceosome; positive regulation of defense response to virus by host |
| NCBI Summary: | The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08579 |
| NCBI GenInfo Identifier: | 134095 |
| NCBI Gene ID: | 6629 |
| NCBI Accession: | P08579.1 |
| UniProt Secondary Accession: | P08579,Q9UJD4, B2R7J3, D3DW21, |
| UniProt Related Accession: | P08579 |
| Molecular Weight: | 25,486 Da |
| NCBI Full Name: | U2 small nuclear ribonucleoprotein B'' |
| NCBI Synonym Full Names: | small nuclear ribonucleoprotein polypeptide B2 |
| NCBI Official Symbol: | SNRPB2�� |
| NCBI Official Synonym Symbols: | Msl1; U2B''�� |
| NCBI Protein Information: | U2 small nuclear ribonucleoprotein B'' |
| UniProt Protein Name: | U2 small nuclear ribonucleoprotein B'' |
| UniProt Gene Name: | SNRPB2�� |
| UniProt Entry Name: | RU2B_HUMAN |
