Description
| Product Name: | Human SNCG Recombinant Protein |
| Product Code: | RPPB4741 |
| Size: | 50µg |
| Species: | Human |
| Target: | SNCG |
| Synonyms: | Gamma-synuclein, Persyn, Breast cancer-specific gene 1 protein, Synoretin, SR, SNCG, BCSG1, PERSYN, PRSN, g-Synuclein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The protein (1mg/ml) contains 20mM Tris-HCl buffer (pH 7.5) and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GAKTKENVVQSVTSVAEKTK EQANAVSEAV VSSVNTVATK TVEEAENIAV TSGVVRKEDL RPSAPQQEGV ASKEKEEVAE EAQSGGD |
g-synuclein(Originally known as a breast cancer specific gene product, BCSG1) is an acidic neuronal protein of 127 amino acids. Gamma-Synuclein is a member of the Synuclein protein family, which is believed to be involved in the pathogenesis of neurodegenerative diseases. High levels of Gamma-Synuclein have been found in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development. Synuclein-Gamma is found mostly in the peripheral nervous system (in primary sensory neurons, sympathetic neurons, and motor neurons) and retina. SNCG is also identified in the brain, ovarian tumors, and in the olfactory epithelium. SNCG expression in breast tumors is a marker for tumor progression. A modification in the expression of gamma-synuclein has been detected in the retina of Alzheimer's patients.
g-Synuclein Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 127 amino acids and having a molecular mass of 13,300 Dalton. The protein coding region of g-synuclein was amplified by RT-PCR and cloned into an E.coli expression vector. g-synuclein was overexpressed in E. coli and purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques.
| UniProt Protein Function: | SNCG: a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. May be involved in modulating axonal architecture during development and in the adult. Plays a role in neurofilament network integrity. High levels have been identified in advanced breast carcinomas. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 10q23.2-q23.3 Cellular Component: cell soma; perinuclear region of cytoplasm; cytoplasm; plasma membrane; microtubule organizing center; spindle; nerve terminal Molecular Function:beta-tubulin binding; alpha-tubulin binding Biological Process: response to drug; synaptic transmission; adult locomotory behavior; protein secretion; regulation of neurotransmitter secretion; synapse organization and biogenesis; response to cocaine; regulation of dopamine secretion |
| NCBI Summary: | This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010] |
| UniProt Code: | O76070 |
| NCBI GenInfo Identifier: | 90110074 |
| NCBI Gene ID: | 6623 |
| NCBI Accession: | O76070.2 |
| UniProt Secondary Accession: | O76070,O15104, Q96P61, |
| UniProt Related Accession: | O76070 |
| Molecular Weight: | 127 |
| NCBI Full Name: | Gamma-synuclein |
| NCBI Synonym Full Names: | synuclein, gamma (breast cancer-specific protein 1) |
| NCBI Official Symbol: | SNCG�� |
| NCBI Official Synonym Symbols: | SR; BCSG1�� |
| NCBI Protein Information: | gamma-synuclein; persyn; synoretin; breast cancer-specific gene 1 protein |
| UniProt Protein Name: | Gamma-synuclein |
| UniProt Synonym Protein Names: | Breast cancer-specific gene 1 protein; Persyn; Synoretin; SR |
| Protein Family: | Gamma-synuclein |
| UniProt Gene Name: | SNCG�� |
| UniProt Entry Name: | SYUG_HUMAN |
