Description
| Product Name: | Human SNCB Recombinant Protein |
| Product Code: | RPPB4740 |
| Size: | 50µg |
| Species: | Human |
| Target: | SNCB |
| Synonyms: | Beta-synuclein, SNCB, b-Synuclein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The protein (1mg/ml) contains 20mM Tris-HCl buffer (pH 7.5), 0.1M NaCl and 1mM MgCl2. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA |
b-synuclein (amino acids 1-134), an acidic neuronal protein of 134 amino acids, is extremely heat-resistant. b-synucelin also has a chaperone-like activity. Recently, b-synuclein has been suggested to inhibit a-synuclein aggregation. b and a-synuclein are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease.
Recombinant Human b-Synuclein produced in E.Coli is a single, non-glycosylated polypeptide chain (1-134 a.a) having a molecular mass of 14.2kDa (molecular size on SDS-PAGE will appear higher).
| UniProt Protein Function: | SNCB: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May play a role in neuronal plasticity, is abundant in neurofibrillary lesions of Alzheimer's patients. Highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 5q35.2 Cellular Component: inclusion body Molecular Function:calcium ion binding; phospholipase inhibitor activity; transition metal ion binding Disease: Dementia, Lewy Body |
| NCBI Summary: | This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q16143 |
| NCBI GenInfo Identifier: | 2501105 |
| NCBI Gene ID: | 6620 |
| NCBI Accession: | Q16143.1 |
| UniProt Secondary Accession: | Q16143,Q6IAX7, |
| UniProt Related Accession: | Q16143 |
| Molecular Weight: | 14kDa |
| NCBI Full Name: | Beta-synuclein |
| NCBI Synonym Full Names: | synuclein beta |
| NCBI Official Symbol: | SNCB�� |
| NCBI Protein Information: | beta-synuclein |
| UniProt Protein Name: | Beta-synuclein |
| Protein Family: | Beta-synuclein |
| UniProt Gene Name: | SNCB�� |
