Description
| Product Name: | Human SLURP1 Dimer Recombinant Protein |
| Product Code: | RPPB4711 |
| Size: | 10µg |
| Species: | Human |
| Target: | SLURP1 Dimer |
| Synonyms: | Secreted LY6/PLAUR Domain Containing 1, Lymphocyte Antigen 6-Like Secreted, Anti-Neoplastic Urinary Protein, ARS(Component B)-81/S, ARS Component B, SLURP-1, ANUP, ARS, Secreted Ly6/UPAR Related Protein 1, LY6LS, ArsB, MDM, SLURP1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | SLURP1 was filtered (0.4�m) and lyophilized from 0.5mg/ml solution in 20mM Tris buffer and 50mM NaCl, pH 8.0. |
| Solubility: | It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. SLURP1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHLK CYTCKEPMTS ASCRTITRCK PEDTACMTTL VTVEAEYPFN QSPVVTRSCS SSCVATDPDS IGAAHLIFCC FRDLCNSEL |
Secreted LY6/PLAUR Domain Containing 1 (SLURP1) belongs to the Ly6/uPAR family though lacks a GPI-anchoring signal sequence. It is assumed that the SLURP1 protein contains antitumor activity. SLURP1 is a marker of late differentiation of the skin. SLURP1 has been implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. The SLURP1 gene maps to the same chromosomal region as some members of the Ly6/uPAR family of glycoprotein receptors. SLURP1 gene mutations are linked with Mal de Meleda, a rare autosomal recessive skin disorder.
SLURP1 Human Recombinant produced in E.Coli is a non-glycosylated homodimer (Leu23-leu103) containing 2x89 amino acids including an 8 aa His tag at N-terminus. The total calculated molecular mass for each chain is 9.9kDa.
| UniProt Protein Function: | SLURP1: Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. Defects in SLURP1 are a cause of Mal de Meleda (MDM); also known as keratosis palmoplantaris transgradiens of Siemens. MDM is a rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: extracellular space; extracellular region Molecular Function:cytokine activity Biological Process: cell activation; neuromuscular process controlling posture; locomotory behavior; cell adhesion Disease: Mal De Meleda |
| NCBI Summary: | The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P55000 |
| NCBI GenInfo Identifier: | 3287957 |
| NCBI Gene ID: | 57152 |
| NCBI Accession: | P55000.2 |
| UniProt Secondary Accession: | P55000,Q53YJ6, Q6PUA6, Q92483, |
| UniProt Related Accession: | P55000 |
| Molecular Weight: | 11kDa |
| NCBI Full Name: | Secreted Ly-6/uPAR-related protein 1 |
| NCBI Synonym Full Names: | secreted LY6/PLAUR domain containing 1 |
| NCBI Official Symbol: | SLURP1�� |
| NCBI Official Synonym Symbols: | ARS; MDM; ANUP; ArsB; LY6LS�� |
| NCBI Protein Information: | secreted Ly-6/uPAR-related protein 1; SLURP-1; ARS(component B)-81/S; anti-neoplastic urinary protein; lymphocyte antigen 6-like secreted; secreted Ly6/uPAR related protein 1 |
| UniProt Protein Name: | Secreted Ly-6/uPAR-related protein 1 |
| UniProt Synonym Protein Names: | ARS component B; ARS(component B)-81/S; Anti-neoplastic urinary protein; ANUP |
| Protein Family: | Secreted Ly-6/uPAR-related protein |
| UniProt Gene Name: | SLURP1�� |
| UniProt Entry Name: | SLUR1_HUMAN |
