Description
| Product Name: | Human SLAMF1 Recombinant Protein |
| Product Code: | RPPB4701 |
| Size: | 10µg |
| Species: | Human |
| Target: | SLAMF1 |
| Synonyms: | Signaling lymphocytic activation molecule, CDw150, IPO-3, CD150, SLAMF1, SLAM. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SLAMF1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSASYGTGG RMMNCPKILR QLGSKVLLPL TYERINKSMN KSIHIVVTMA KSLENSVENK IVSLDPSEAG PPRYLGDRYK FYLENLTLGI RESRKEDEGW YLMTLEKNVS VQRFCLQLRL YEQVSTPEIK VLNKTQENGT CTLILGCTVE KGDHVAYSWS EKAGTHPLNP ANSSHLLSLT LGPQHADNIY ICTVSNPISN NSQTFSPWPG CRTDPSETKP |
SLAMF1 is a member of the immunoglobulin gene superfamily and is involved in T-cell stimulation. The SLAMF1 protein is constitutively expressed on peripheral blood memory T cells, T-cell clones, immature thymocytes, and a fraction of B cells, and is swiftly induced on naive T cells after activation. There are probably 2 modes of SLAM signaling: one in which the inhibitor SH2D1A serves as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction functions.
SLAMF1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 240 amino acids (21-237 a.a) and having a molecular mass of 26.7kDa.SLAMF1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SLAM: a type I membrane protein present on the surface of B cells, T cells and CD83+ dendritic cells. A high-affinity self-ligand considered to be important in bidirectional T <-> B-cell stimulation. SLAM-induced signal-transduction events in T lymphocytes are different from those in B cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A (SAP) acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (SHP-2)-dependent signal transduction operates. Its cytoplasmic domain interacts with SAP through part of its SH2 domain, and with SHP-2. Three alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q23.3 Cellular Component: integral to membrane; phagocytic vesicle; external side of plasma membrane Molecular Function:protein binding; transmembrane receptor activity; antigen binding Biological Process: viral reproduction; regulation of catalytic activity; positive regulation of cell proliferation; regulation of vesicle fusion; lymphocyte activation; signal transduction |
| UniProt Code: | Q13291 |
| NCBI GenInfo Identifier: | 9297047 |
| NCBI Gene ID: | 6504 |
| NCBI Accession: | Q13291.1 |
| UniProt Secondary Accession: | Q13291,Q5W172, Q9HBE8, |
| UniProt Related Accession: | Q13291 |
| Molecular Weight: | 335 |
| NCBI Full Name: | Signaling lymphocytic activation molecule |
| NCBI Synonym Full Names: | signaling lymphocytic activation molecule family member 1 |
| NCBI Official Symbol: | SLAMF1�� |
| NCBI Official Synonym Symbols: | SLAM; CD150; CDw150�� |
| NCBI Protein Information: | signaling lymphocytic activation molecule; IPO-3 |
| UniProt Protein Name: | Signaling lymphocytic activation molecule |
| UniProt Synonym Protein Names: | CDw150; IPO-3; CD_antigen: CD150 |
| Protein Family: | SLAM family |
| UniProt Gene Name: | SLAMF1�� |
| UniProt Entry Name: | SLAF1_HUMAN |
