Description
| Product Name: | Human SIRPB1 Recombinant Protein |
| Product Code: | RPPB4688 |
| Size: | 10µg |
| Species: | Human |
| Target: | SIRPB1 |
| Synonyms: | SIRPB1, CD172b, SIRP-BETA-1, SIRP-Beta-1 Isoform 3, CD172b Antigen, CD172b. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SIRPB1protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | EDELQVIQPE KSVSVAAGES ATLRCAMTSL IPVGPIMWFR GAGAGRELIY NQKEGHFPRV TTVSELTKRN NLDFSISISN ITPADAGTYY CVKFRKGSPD DVEFKSGAGT ELSVRAKPSA PVVSGPAVRA TPEHTVSFTC ESHGFSPRDI TLKWFKNGNE LSDFQTNVDP AGDSVSYSIH STARVVLTRG DVHSQVICEI AHITLQGDPL RGTANLSEAI RVPPTLEVTQ QPMRAENQAN VTCQVSNFYP RGLQLTWLEN GNVSRTETAS TLIENKDGTY NWMSWLLVNT CAHRDDVVLT CQVEHDGQQA VSKSYALEIS AHQKEHGSDI THEAALAPTA PLHHHHHH |
Signal-regulatory protein beta-1 isoform 1 or SIRPB1, is an immunoglobulin-like cell surface receptor which is a part of the SIRP superfamily. SIRPB1 is a cell membrane receptor that takes part in the negative regulation of tyrosine kinase-coupled signaling pathway. SIRPB1 is engaged in the activation of tyrosine kinase SYK, SIRP alpha molecules (activates SHP-1 and SHP-2 protein tyrosine phosphatases), etc.��
SIRPB1produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (30-371 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 348 amino acids and having a molecular mass of 38.0kDa. SIRPB1shows multiple bands between 40-57kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SIRPB1: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 20p13Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: protein bindingBiological Process: cell surface receptor linked signal transduction; innate immune response; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
| UniProt Code: | O00241 |
| NCBI GenInfo Identifier: | 311033545 |
| NCBI Gene ID: | 10326 |
| NCBI Accession: | O00241.5 |
| UniProt Secondary Accession: | O00241,Q5TFQ9, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0, A6NLM2 B2R8V0 |
| UniProt Related Accession: | O00241,Q5TFQ8, O00241 |
| Molecular Weight: | 43,359 Da |
| NCBI Full Name: | Signal-regulatory protein beta-1 |
| NCBI Synonym Full Names: | signal regulatory protein beta 1 |
| NCBI Official Symbol: | SIRPB1�� |
| NCBI Official Synonym Symbols: | CD172b; SIRP-BETA-1�� |
| NCBI Protein Information: | signal-regulatory protein beta-1 |
| UniProt Protein Name: | Signal-regulatory protein beta-1 |
| UniProt Synonym Protein Names: | CD172 antigen-like family member B; CD_antigen: CD172b |
| Protein Family: | Signal-regulatory protein |
| UniProt Gene Name: | SIRPB1�� |
| UniProt Entry Name: | SIRB1_HUMAN |
