Description
| Product Name: | Human SHBG Recombinant Protein |
| Product Code: | RPPB4668 |
| Size: | 10µg |
| Species: | Human |
| Target: | SHBG |
| Synonyms: | Sex hormone-binding globulin, SHBG, Sex steroid-binding protein, SBP, Testis-specific androgen-binding protein, ABP, Testosterone-estradiol-binding globulin, TeBG, Testosterone-estrogen-binding globulin, SHBG. |
| Source: | Chinese Hamster Ovary Cells (CHO) |
| Physical Appearance: | Filtered colorless solution. |
| Formulation: | SHBG filtered solution at a concentration of 55.6�g/ml in certified FBS (Fetal Bovine Serum 5%). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Amino Acid Sequence: | AAQPARRARR TKLLLLLLLL LRHTRQGWAL RPVLPTQSAH DPPAVHLSNG PGQEPIAVMT FDLTKITKTS SSFEVRTWDP EGVIFYGDTN PKDDWFMLGL RDGRPEIQLH NHWAQLTVGA GPRLDDGRWH QVEVKMEGDS VLLEVDGEEV LRLRQVSGPL TSKRHPIMRI ALGGLLFPAS NLRLPLVPAL DGCLRRDSWL DKQAEISASA PTSLRSCDVE SNPGIFLPPG TQAEFNLRDI PQPHAEPWAF SLDLGLKQAA GSGHLLALGT PENPSWLSLH LQDQKVVLSS GSGPGLDLPL VLGLPLQLKL SMSRVVLSQG SKMKALALPP LGLAPLLNLW AKPQGRLFLG ALPGEDSSTS FCLNGLWAQG QRLDVDQALN RSHEIWTHSC PQSPGNGTDA SHSRGGPEQKLISEEDLNSA VDHHHHHH |
Sex-hormone-binding globulin (SHBG) is a beta-globulin which specifically binds steroid hormones; it is involved in the transport of sex steroids in plasma. The main site of SHBG synthesis is assumed to be the hepatocytes. The production of SHBG is regulated by androgen/estrogen balance, thyroid hormones, and dietary factors, among others. The concentration of SHBG is a key factor regulating their distribution between protein-bound and free states. SHBG concentration determination is primarily significant in the evaluation of mild disorders of androgen metabolism and it allows detection of women with hirsutism who are likely to react to estrogen therapy. Testosterone/SHBG-ratios correlate well with both measured and calculated values for free testosterone thus aid to distinguish between subjects with excessive androgen activity and normal individuals. SHBG gene polymorphisms are linked with polycystic ovary syndrome and type 2 diabetes mellitus.
SHBG Human Recombinant produced in CHO cells is a single, glycosylated, polypeptide chain containing a total of 428 amino acids, having a molecular mass of 46.79kDa (calculated), the SHBG is fused to a 6 a.a C-terminal His tag and also includes a myc-epitope.The Human SHBG is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SHBG: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: extracellular region Molecular Function:androgen binding Biological Process: primary spermatocyte growth |
| NCBI Summary: | This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009] |
| UniProt Code: | P04278 |
| NCBI GenInfo Identifier: | 7382460 |
| NCBI Gene ID: | 6462 |
| NCBI Accession: | NP_001031.2 |
| UniProt Secondary Accession: | P04278,P14689, Q16616, Q3MIL0, Q6ISD2, B0FWH4, E9PGW1 F5H5Z8, I3L1N7, |
| UniProt Related Accession: | P04278 |
| Molecular Weight: | 43,779 Da |
| NCBI Full Name: | sex hormone-binding globulin isoform 1 |
| NCBI Synonym Full Names: | sex hormone-binding globulin |
| NCBI Official Symbol: | SHBG�� |
| NCBI Official Synonym Symbols: | ABP; SBP; TEBG�� |
| NCBI Protein Information: | sex hormone-binding globulin; sex steroid-binding protein; testosterone-binding beta-globulin; testosterone-estrogen-binding globulin; testosterone-estradiol-binding globulin; testis-specific androgen-binding protein |
| UniProt Protein Name: | Sex hormone-binding globulin |
| UniProt Synonym Protein Names: | Sex steroid-binding protein; SBP; Testis-specific androgen-binding protein; ABP; Testosterone-estradiol-binding globulin; TeBG; Testosterone-estrogen-binding globulin |
| Protein Family: | Sex hormone-binding globulin |
| UniProt Gene Name: | SHBG�� |
| UniProt Entry Name: | SHBG_HUMAN |
