Description
| Product Name: | Human SH3GLB2 Recombinant Protein |
| Product Code: | RPPB4677 |
| Size: | 20µg |
| Species: | Human |
| Target: | SH3GLB2 |
| Synonyms: | PP6569, PP9455, Endophilin-B2, KIAA1848, SH3 domain-containing GRB2-like protein B2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SH3GLB2 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDFNMKK LASDAGIFFT RAVQFTEEKF GQAEKTELDA HFENLLARAD STKNWTEKIL RQTEVLLQPN PSARVEEFLY EKLDRKVPSR VTNGELLAQY MADAASELGP TTPYGKTLIK VAEAEKQLGA AERDFIHTAS ISFLTPLRNF LEGDWKTISK ERRLLQNRRL DLDACKARLK KAKAAEAKAT TVPDFQETRP RNYILSASAS ALWNDEVDKA EQELRVAQTE FDRQAEVTRL LLEGISSTHV NHLRCLHEFV KSQTTYYAQC YRHMLDLQKQ LGRFPGTFVG TTEPASPPLS STSPTTAAAT MPVVPSVASL APPGEASLCL EEVAPPASGT RKARVLYDYE AADSSELALL ADELITVYSL PGMDPDWLIG ERGNKKGKVP VTYLELLS |
Endophilin-B2 (SH3GLB2) belongs to the endophilin B subgroup. The endophilins comprise a family of proteins that relates with amphiphysin, synaptojanin and dynamin and are involved in presynaptic vesicle trafficking at nerve terminals.The expression patterns of the endophilins are coherent with their cellular functions at the neuronal synapse. SH3GLB2 is ubiquitously expressed however presents highest levels in brain, adult lung, ovary, and spinal cord.Low levels of SH3GLB2�are found in Down syndrome and reflect brain dysgenesis.
SH3GLB2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 418 amino acids (1-395a.a.) and having a molecular mass of 46.4 kDa. SH3GLB2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SH3GLB2: Belongs to the endophilin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Autophagy Chromosomal Location of Human Ortholog: 9q34.11 Cellular Component: cytoplasm; cytosol; nucleoplasm Molecular Function:cadherin binding; identical protein binding; protein binding |
| UniProt Code: | Q9NR46 |
| NCBI GenInfo Identifier: | 559098444 |
| NCBI Gene ID: | 56904 |
| NCBI Accession: | NP_001273974.1 |
| UniProt Secondary Accession: | Q9NR46,Q8WY61, Q96JH9, A6NC47, A8MPS4, |
| UniProt Related Accession: | Q9NR46 |
| Molecular Weight: | 59.9kD |
| NCBI Full Name: | endophilin-B2 isoform a |
| NCBI Synonym Full Names: | SH3 domain containing GRB2 like, endophilin B2 |
| NCBI Official Symbol: | SH3GLB2�� |
| NCBI Official Synonym Symbols: | RRIG1; PP6569; PP9455�� |
| NCBI Protein Information: | endophilin-B2 |
| UniProt Protein Name: | Endophilin-B2 |
| UniProt Synonym Protein Names: | SH3 domain-containing GRB2-like protein B2 |
| Protein Family: | Endophilin |
| UniProt Gene Name: | SH3GLB2�� |
