Description
| Product Name: | Human SH3GL2 Recombinant Protein |
| Product Code: | RPPB4675 |
| Size: | 20µg |
| Species: | Human |
| Target: | SH3GL2 |
| Synonyms: | Endophilin-A1, EEN-B1, Endophilin-1, SH3 domain protein 2A, SH3 domain-containing, GRB2-like protein 2, SH3GL2, CNSA2, SH3D2A, SH3P4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SH3GL2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer, pH8.0, 10% glycerol, 1mM DTT and 50mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMSVAGL KKQFHKATQK VSEKVGGAEG TKLDDDFKEM ERKVDVTSRA VMEIMTKTIE YLQPNPASRA KLSMINTMSK IRGQEKGPGY PQAEALLAEA MLKFGRELGD DCNFGPALGE VGEAMRELSE VKDSLDIEVK QNFIDPLQNL HDKDLREIQH HLKKLEGRRL DFDYKKKRQG KIPDEELRQA LEKFDESKEI AESSMFNLLE MDIEQVSQLS ALVQAQLEYH KQAVQILQQV TVRLEERIRQ ASSQPRREYQ PKPRMSLEFP TGDSTQPNGG LSHTGTPKPS GVQMDQPCCR ALYDFEPENE GELGFKEGDI ITLTNQIDEN WYEGMLHGHS GFFPINYVEI LVALPH |
SH3-domain GRB2-like 2 (SH3GL2) is a member of the endophilin family. SH3GL2 contains a BAR domain and a SH3 domain. Members of the BAR domain protein superfamily are crucial elements of cellular traffic. Endophilins have a major function in synaptic vesicle endocytosis (SVE), receptor trafficking and apoptosis, and in other processes which require remodeling of the membrane structure. SH3GL2 is a novel tumor suppressor gene in laryngeal squamous cell carcinoma (LSCC), which induces apoptosis of tumor cells by regulating intra-cellular signal transduction networks. SH3GL2 is implicated in synaptic vesicle endocytosis. SH3GL2 is found in the brain, mainly in frontal cortex, and at high level in the fetal cerebellum.
SH3GL2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 376 amino acids (1-352 a.a) and having a molecular mass of 42.5kDa.SH3GL2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | endophilin 1: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Belongs to the endophilin family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Membrane protein, peripheral; Vesicle Chromosomal Location of Human Ortholog: 9p22 Cellular Component: cytosol; Golgi membrane; plasma membrane Molecular Function:identical protein binding; protein binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; central nervous system development; microtubule-based movement; negative regulation of epidermal growth factor receptor signaling pathway; signal transduction |
| UniProt Code: | Q99962 |
| NCBI GenInfo Identifier: | 10720276 |
| NCBI Gene ID: | 6456 |
| NCBI Accession: | Q99962.1 |
| UniProt Secondary Accession: | Q99962,Q9NQK5, B2R618, |
| UniProt Related Accession: | Q99962 |
| Molecular Weight: | 39,962 Da |
| NCBI Full Name: | Endophilin-A1 |
| NCBI Synonym Full Names: | SH3 domain containing GRB2 like 2, endophilin A1 |
| NCBI Official Symbol: | SH3GL2�� |
| NCBI Official Synonym Symbols: | CNSA2; SH3P4; EEN-B1; SH3D2A�� |
| NCBI Protein Information: | endophilin-A1 |
| UniProt Protein Name: | Endophilin-A1 |
| UniProt Synonym Protein Names: | EEN-B1; Endophilin-1; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2 |
| Protein Family: | Endophilin |
| UniProt Gene Name: | SH3GL2�� |
| UniProt Entry Name: | SH3G2_HUMAN |
