Description
| Product Name: | Human SERPIND1 Recombinant Protein |
| Product Code: | RPPB4643 |
| Size: | 20µg |
| Species: | Human |
| Target: | SERPIND1 |
| Synonyms: | Serpin Family D Member 1, Cysteine Proteinase Inhibitor Clade D Member 1, Serpin Peptidase Inhibitor Clade D Member 1, Protease Inhibitor Leuserpin-2, Serpin D1, HCF2, HLS2, Leuserpin 2, D22S673, THPH10, HC-II, HCII, HC2, LS2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SERPIND1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSDFHKENT VTNDWIPEGE EDDDYLDLEK IFSEDDDYID IVDSLSVSPT DSDVSAGNIL QLFHGKSRIQ RLNILNAKFA FNLYRVLKDQ VNTFDNIFIA PVGISTAMGM ISLGLKGETH EQVHSILHFK DFVNASSKYE ITTIHNLFRK LTHRLFRRNF GYTLRSVNDL YIQKQFPILL DFKTKVREYY FAEAQIADFS DPAFISKTNN HIMKLTKGLI KDALENIDPA TQMMILNCIY FKGSWVNKFP VEMTHNHNFR LNEREVVKVS MMQTKGNFLA ANDQELDCDI LQLEYVGGIS MLIVVPHKMS GMKTLEAQLT PRVVERWQKS MTNRTREVLL PKFKLEKNYN LVESLKLMGI RMLFDKNGNM AGISDQRIAI DLFKHQGTIT VNEEGTQATT VTTVGFMPLS TQVRFTVDRP FLFLIYEHRT SCLLFMGRVA NPSRS |
Serpin Peptidase Inhibitor, Clade D Member 1 (SERPIND1) is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate. SERPIND1 gene is a member of the serpin gene superfamily. SERPIND1 protein contains 5 exons and 4 introns. SERPIND1 shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. SERPIND1 gene mutations are linked with cofactor II deficiency. SERPIND1 protein is activated by dermatan sulfate, and glycosaminoglycans. Allelic variations in the SERPIND1 gene are linked with cofactor II deficiency.
SERPIND1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 465 amino acids (58-499) and having a molecular mass of 53.3kDa.SERPIND1 is fused to a 23 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SERPIND1: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Defects in SERPIND1 are the cause of thrombophilia due to heparin cofactor 2 deficiency (THPH10). A hemostatic disorder characterized by a tendency to recurrent thrombosis. Belongs to the serpin family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 22q11.21 Cellular Component: extracellular space; extracellular region Molecular Function:heparin binding; serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity Biological Process: chemotaxis; blood coagulation Disease: Heparin Cofactor Ii Deficiency |
| NCBI Summary: | The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05546 |
| NCBI GenInfo Identifier: | 123055 |
| NCBI Gene ID: | 3053 |
| NCBI Accession: | P05546.3 |
| UniProt Secondary Accession: | P05546,Q6IBZ5, B2RAI1, D3DX34, |
| UniProt Related Accession: | P05546 |
| Molecular Weight: | 499 |
| NCBI Full Name: | Heparin cofactor 2 |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 |
| NCBI Official Symbol: | SERPIND1�� |
| NCBI Official Synonym Symbols: | HC2; LS2; HCF2; HCII; HLS2; THPH10; D22S673�� |
| NCBI Protein Information: | heparin cofactor 2; serpin D1; leuserpin 2; protease inhibitor leuserpin-2; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 |
| UniProt Protein Name: | Heparin cofactor 2 |
| UniProt Synonym Protein Names: | Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2; HLS2; Serpin D1 |
| Protein Family: | Heparin cofactor |
| UniProt Gene Name: | SERPIND1�� |
| UniProt Entry Name: | HEP2_HUMAN |
