Description
| Product Name: | Human SERPINB8 Recombinant Protein |
| Product Code: | RPPB4640 |
| Size: | 20µg |
| Species: | Human |
| Target: | SERPINB8 |
| Synonyms: | CAP2, PI8, Serpin B8, Cytoplasmic antiproteinase 2, Peptidaseinhibitor 8, CAP-2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | SERPINB8 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDDLCEA NGTFAISLFK ILGEEDNSRN VFFSPMSISS ALAMVFMGAKGSTAAQMSQA LCLYKDGDIH RGFQSLLSEV NRTGTQYLLR TANRLFGEKT CDFLPDFKEY CQKFYQAELEELSFAEDTEE CRKHINDWVA EKTEGKISEV LDAGTVDPLT KLVLVNAIYF KGKWNEQFDR KYTRGMLFKTNEEKKTVQMM FKEAKFKMGY ADEVHTQVLE LPYVEEELSM VILLPDDNTD LAVVEKALTY EKFKAWTNSEKLTKSKVQVF LPRLKLEESY DLEPFLRRLG MIDAFDEAKA DFSGMSTEKN VPLSKVAHKC FVEVNEEGTEAAAATAVVRN SRCSRMEPRF CADHPFLFFI RHHKTNCILF CGRFSSP |
Serpin Peptidase Inhibitor, Clade B Member 8 (SERPINB8) belongs to the ov-serpin subfamily, which, compared with the archetypal serpin PI1, is characterized by a high degree of homology to chicken ovalbumin, absence of N- and C-terminal extensions, lack of a signal peptide, and a serine instead of an asparagine residue at the penultimate position. The superfamily of high molecular weight serine proteinase inhibitors (serpins) control various intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration.
SERPINB8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 397 amino acids (1-374 a.a) and having a molecular mass of 45.2kDa.SERPINB8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SERPINB8: Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing |
| UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 18q22.1 Cellular Component: extracellular space; cytosol Molecular Function:serine-type endopeptidase inhibitor activity; protein binding |
| NCBI Summary: | The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010] |
| UniProt Code: | P50452 |
| NCBI GenInfo Identifier: | 73623033 |
| NCBI Gene ID: | 5271 |
| NCBI Accession: | NP_001027018.1 |
| UniProt Secondary Accession: | P50452,Q7Z2V6, Q8N178, B4DTW2, |
| UniProt Related Accession: | P50452 |
| Molecular Weight: | 22,134 Da |
| NCBI Full Name: | serpin B8 isoform b |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade B (ovalbumin), member 8 |
| NCBI Official Symbol: | SERPINB8�� |
| NCBI Official Synonym Symbols: | PI8; CAP2�� |
| NCBI Protein Information: | serpin B8 |
| UniProt Protein Name: | Serpin B8 |
| UniProt Synonym Protein Names: | Cytoplasmic antiproteinase 2; CAP-2; CAP2; Peptidase inhibitor 8; PI-8 |
| UniProt Gene Name: | SERPINB8�� |
| UniProt Entry Name: | SPB8_HUMAN |
