Description
| Product Name: | Human SERPINB4 Recombinant Protein |
| Product Code: | RPPB4637 |
| Size: | 10µg |
| Species: | Human |
| Target: | SERPINB4 |
| Synonyms: | SERPINB4,Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member, Squamous CellCarcinoma, Antigen, SCCA2, Serine (Or Cysteine) Proteinase Inhibitor, Clade B(Ovalbumin), Member, Peptidase Inhibitor, LEUPIN, SCCA, PI11, ProteaseInhibitor (Leucine-Serpin) Squamous Cell Carcinoma Antigen, SCCA2/SCCA1 FusionProtein, Serpin B4, SCCA1 PI-11. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | SERPINB4 protein solution (0.5mg/ml) containing Phosphatebuffered saline (pH7.4), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMEDLCVA NTLFALNLFK HLAKASPTQN LFLSPWSISS TMAMVYMGSR GSTEDQMAKV LQFNEVGANA VTPMTPENFT SCGFMQQIQK GSYPDAILQA QAADKIHSSF RSLSSAINAS TGNYLLESVN KLFGEKSASF REEYIRLCQK YYSSEPQAVD FLECAEEARK KINSWVKTQT KGKIPNLLPE GSVDGDTRMV LVNAVYFKGK WKTPFEKKLN GLYPFRVNSA QRTPVQMMYL REKLNIGYIE DLKAQILELP YAGDVSMFLL LPDEIADVST GLELLESEIT YDKLNKWTSK DKMAEDEVEV YIPQFKLEEH YELRSILRSM GMEDAFNKGR ANFSGMSERN DLFLSEVFHQ AMVDVNEEGT EAAAGTGGVM TGRTGHGGPQ FVADHPFLFL IMHKITNCIL FFGRFSSP |
Serpin Peptidase Inhibitor, Clade B Member 4, also known as SERPINB4 isa member of the serpin family. SERPINB4 acts as a protease inhibitor tomodulate the host immune response against tumor cells. Among the diseases associatedwith SERPINB4 are: inverted papilloma as well as burns.
SERPINB4 Human Recombinant produced in E.Coli is asingle, non-glycosylated polypeptide chain containing 413 amino acids (1-390 a.a)and having a molecular mass of 47.2kDa.SERPINB4 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SERPINB4: May act as a protease inhibitor to modulate the host immune response against tumor cells. Belongs to the serpin family. Ov-serpin subfamily. |
| UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 18q21.3 Cellular Component: extracellular space; intracellular Molecular Function:enzyme binding; protease binding; serine-type endopeptidase inhibitor activity Biological Process: negative regulation of peptidase activity; protection from natural killer cell mediated cytotoxicity |
| UniProt Code: | P48594 |
| NCBI GenInfo Identifier: | 1710877 |
| NCBI Gene ID: | 6318 |
| NCBI Accession: | P48594.2 |
| UniProt Secondary Accession: | P48594,A8K847, |
| UniProt Related Accession: | P48594 |
| Molecular Weight: | 44,854 Da |
| NCBI Full Name: | Serpin B4 |
| NCBI Synonym Full Names: | serpin family B member 4 |
| NCBI Official Symbol: | SERPINB4�� |
| NCBI Official Synonym Symbols: | PI11; SCCA1; SCCA2; LEUPIN; SCCA-2�� |
| NCBI Protein Information: | serpin B4 |
| UniProt Protein Name: | Serpin B4 |
| UniProt Synonym Protein Names: | Leupin; Peptidase inhibitor 11; PI-11; Squamous cell carcinoma antigen 2; SCCA-2 |
| Protein Family: | Serpin |
| UniProt Gene Name: | SERPINB4�� |
| UniProt Entry Name: | SPB4_HUMAN |
