Description
| Product Name: | Human SERPINB2 Recombinant Protein |
| Product Code: | RPPB4635 |
| Size: | 10µg |
| Species: | Human |
| Target: | SERPINB2 |
| Synonyms: | Plasminogen activator inhibitor 2, PAI-2, Plasminogen activator inhibitor 2, SERPINB2, Serpin Peptidase Inhibitor, Clade B Member 2, His Tag, PLANH2, Monocyte Arg-serpin, Placental plasminogen activator inhibitor, Serpin B2, Urokinase inhibitor, HsT1201, PAI, PAI2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | SERPINB2 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH7.4), 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMEDLCVA NTLFALNLFK HLAKASPTQN LFLSPWSISS TMAMVYMGSR GSTEDQMAKV LQFNEVGANA VTPMTPENFT SCGFMQQIQK GSYPDAILQA QAADKIHSSF RSLSSAINAS TGNYLLESVN KLFGEKSASF REEYIRLCQK YYSSEPQAVD FLECAEEARK KINSWVKTQT KGKIPNLLPE GSVDGDTRMV LVNAVYFKGK WKTPFEKKLN GLYPFRVNSA QRTPVQMMYL REKLNIGYIE DLKAQILELP YAGDVSMFLL LPDEIADVST GLELLESEIT YDKLNKWTSK DKMAEDEVEV YIPQFKLEEH YELRSILRSM GMEDAFNKGR ANFSGMSERN DLFLSEVFHQ AMVDVNEEGT EAAAGTGGVM TGRTGHGGPQ FVADHPFLFL IMHKITNCIL FFGRFSSP |
SERPINB2 is an inhibitory serpin produced primarily in keratinocytes, stimulated monocytes, and placental trophoblasts. SERPINB2 is found primarily as a 47 kDa non-glycosylated intracellular protein that is induced to be secreted as 60 kDa glycoprotein. The glycosylated and unglycosylated SERPINB2 are similarly effective as inhibitors of urokinase-type plasminogen activator (uPA), the only proven physiological target of SERPINB2.
SERPINB2 Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 438 amino acids (1-415 a.a.) and having a molecular mass of 49kDa.SERPINB2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SERPINB2: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1. Belongs to the serpin family. Ov-serpin subfamily. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 18q21.3 Cellular Component: extracellular space; cytoplasm; plasma membrane; extracellular region Molecular Function:serine-type endopeptidase inhibitor activity Biological Process: fibrinolysis; blood coagulation; negative regulation of apoptosis |
| UniProt Code: | P05120 |
| NCBI GenInfo Identifier: | 1352712 |
| NCBI Gene ID: | 5055 |
| NCBI Accession: | P05120.2 |
| UniProt Secondary Accession: | P05120,Q96E96, |
| UniProt Related Accession: | P05120 |
| Molecular Weight: | 46,596 Da |
| NCBI Full Name: | Plasminogen activator inhibitor 2 |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade B (ovalbumin), member 2 |
| NCBI Official Symbol: | SERPINB2�� |
| NCBI Official Synonym Symbols: | PAI; PAI2; PAI-2; PLANH2; HsT1201�� |
| NCBI Protein Information: | plasminogen activator inhibitor 2; serpin B2; monocyte Arg-serpin; urokinase inhibitor; placental plasminogen activator inhibitor; plasminogen activator inhibitor, type II (arginine-serpin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 |
| UniProt Protein Name: | Plasminogen activator inhibitor 2 |
| UniProt Synonym Protein Names: | Monocyte Arg-serpin; Placental plasminogen activator inhibitor; Serpin B2; Urokinase inhibitor |
| UniProt Gene Name: | SERPINB2�� |
| UniProt Entry Name: | PAI2_HUMAN |
