Description
| Product Name: | Human SDCBP2 Recombinant Protein |
| Product Code: | RPPB4604 |
| Size: | 10µg |
| Species: | Human |
| Target: | SDCBP2 |
| Synonyms: | SITAC, SITAC18, ST-2, Syntenin-2, Syndecan-binding protein 2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | SDCBP2 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSSLYPS LEDLKVDQAI QAQVRASPKM PALPVQATAI SPPPVLYPNL AELENYMGLS LSSQEVQESL LQIPEGDSTA VSGPGPGQMV APVTGYSLGV RRAEIKPGVR EIHLCKDERG KTGLRLRKVD QGLFVQLVQA NTPASLVGLR FGDQLLQIDG RDCAGWSSHK AHQVVKKASG DKIVVVVRDR PFQRTVTMHK DSMGHVGFVI KKGKIVSLVK GSSAARNGLL TNHYVCEVDG QNVIGLKDKK IMEILATAGN VVTLTIIPSV IYEHMVKKLP PVLLHHTMDH SIPDA |
SDCBP2 has two class II PDZ domains. PDZ domains assist protein-protein interactions by attaching to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. SDCBP2 attaches to phosphatidylinositol 4, 5-bisphosphate (PIP2) and take part in nuclear PIP2 arrangement and cell division.
SDCBP2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 315 amino acids (1-292 a.a.) and having a molecular mass of 34.0kDa. SDCBP2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997). |
| NCBI Summary: | The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q9H190 |
| NCBI GenInfo Identifier: | 20455288 |
| NCBI Gene ID: | 27111 |
| NCBI Accession: | Q9H190.2 |
| UniProt Secondary Accession: | Q9H190,O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8, |
| UniProt Related Accession: | Q9H190 |
| Molecular Weight: | 22,664 Da |
| NCBI Full Name: | Syntenin-2 |
| NCBI Synonym Full Names: | syndecan binding protein 2 |
| NCBI Official Symbol: | SDCBP2�� |
| NCBI Official Synonym Symbols: | ST2; ST-2; SITAC; SITAC18�� |
| NCBI Protein Information: | syntenin-2 |
| UniProt Protein Name: | Syntenin-2 |
| UniProt Synonym Protein Names: | Similar to TACIP18 |
| Protein Family: | High affinity sulfate transporter |
| UniProt Gene Name: | SDCBP2�� |
