Description
| Product Name: | Human SDC1 Recombinant Protein |
| Product Code: | RPPB4600 |
| Size: | 20µg |
| Species: | Human |
| Target: | SDC1 |
| Synonyms: | Heparan Sulfate proteoglycan fibroblast growth factor receptor, syndecan proteoglycan 1, Syndecan 1, SYND1, CD138 antigen, SDC. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SDC1 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM Nacl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMQPALP QIVATNLPPE DQDGSGDDSD NFSGSGAGAL QDITLSQQTP STWKDTQLLT AIPTSPEPTG LEATAASTST LPAGEGPKEG EAVVLPEVEP GLTAREQEAT PRPRETTQLP TTHQASTTTA TTAQEPATSH PHRDMQPGHH ETSTPAGPSQ ADLHTPHTED GGPSATERAA EDGASSQLPA AEGSGEQDFT FETSGENTAV VAVEPDRRNQ SPVDQGATGA SQGLLDRKEV LG |
CD138 takes a part in cell adhesion. CD138 is expressed on the surface of pre-B cells and plasma cells but is absent from mature B cells. SDC1 is a selective marker for B cell lymphoblastic leukemia and lymphoplasmacytoid leukemia. SDC1 is missing from the apoptotic myeloma cells; therefore is a valuable marker for plasma cell and myeloma cells.
SDC1 Human Recombinant produced in E. coli is a single polypeptide chain containing 262 amino acids (18-254) and having a molecular mass of 27kDa (molecular size on SDS-PAGE will appear higher).SDC1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | syndecan-1: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Belongs to the syndecan proteoglycan family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Extracellular matrix Chromosomal Location of Human Ortholog: 2p24.1 Cellular Component: cell surface; cytoplasm; focal adhesion; Golgi lumen; integral to plasma membrane; lysosomal lumen; plasma membrane Molecular Function:protein binding; protein C-terminus binding Biological Process: cell migration; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; lipoprotein metabolic process; myoblast development; retinoid metabolic process; striated muscle cell development |
| NCBI Summary: | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P18827 |
| NCBI GenInfo Identifier: | 229463011 |
| NCBI Gene ID: | 6382 |
| NCBI Accession: | P18827.3 |
| UniProt Secondary Accession: | P18827,Q53QV0, Q546D3, Q96HB7, D6W523, |
| UniProt Related Accession: | P18827,AAB21434,AAB23935 |
| Molecular Weight: | 32,462 Da |
| NCBI Full Name: | Syndecan-1 |
| NCBI Synonym Full Names: | syndecan 1 |
| NCBI Official Symbol: | SDC1�� |
| NCBI Official Synonym Symbols: | SDC; CD138; SYND1; syndecan�� |
| NCBI Protein Information: | syndecan-1 |
| UniProt Protein Name: | Syndecan-1 |
| UniProt Synonym Protein Names: | CD_antigen: CD138 |
| Protein Family: | COMPASS component |
| UniProt Gene Name: | SDC1�� |
| UniProt Entry Name: | SDC1_HUMAN |
