Description
| Product Name: | Human SCN3B Recombinant Protein |
| Product Code: | RPPB4661 |
| Size: | 10µg |
| Species: | Human |
| Target: | SCN3B |
| Synonyms: | Sodium channel subunit beta-3 precursor, Sodium channel, voltage-gated, type III, beta subunit, HSA243396, SCNB3, KIAA1158. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SCN3B solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSFPVCVEV PSETEAVQGN PMKLRCISCM KREEVEATTV VEWFYRPEGG KDFLIYEYRN GHQEVESPFQ GRLQWNGSKD LQDVSITVLN VTLNDSGLYT CNVSREFEFE AHRPFVKTTR LIPLRVTEEA GEDFTSVVSE |
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. SCN3B is a part of the sodium channel beta subunit gene family whose members are responsible for the generation and propagation of action potentials in neurons and muscle. SCN3B influences the inactivation kinetics of the sodium channel.
SCN3B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 160 amino acids (23-159) and having a molecular mass of 18.1kDa.SCN3B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SCN3B: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. Defects in SCN3B are the cause of Brugada syndrome type 7 (BRGDA7). A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family. |
| UniProt Protein Details: | Protein type:Channel, sodium; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q24.1 Cellular Component: plasma membrane; voltage-gated sodium channel complex; Z disc Molecular Function:sodium channel regulator activity Biological Process: cardiac muscle contraction; membrane depolarization; positive regulation of heart rate Disease: Brugada Syndrome 7 |
| NCBI Summary: | Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NY72 |
| NCBI GenInfo Identifier: | 12229762 |
| NCBI Gene ID: | 55800 |
| NCBI Accession: | Q9NY72.1 |
| UniProt Secondary Accession: | Q9NY72,Q17RL3, Q9ULR2, A5H1I5, |
| UniProt Related Accession: | Q9NY72 |
| Molecular Weight: | Calculated: 24kDaObserved: 30kDa |
| NCBI Full Name: | Sodium channel subunit beta-3 |
| NCBI Synonym Full Names: | sodium voltage-gated channel beta subunit 3 |
| NCBI Official Symbol: | SCN3B�� |
| NCBI Official Synonym Symbols: | SCNB3; ATFB16; BRGDA7; HSA243396�� |
| NCBI Protein Information: | sodium channel subunit beta-3 |
| UniProt Protein Name: | Sodium channel subunit beta-3 |
| Protein Family: | Sodium channel |
| UniProt Gene Name: | SCN3B�� |
