Description
| Product Name: | Human SCGB3A2 Recombinant Protein |
| Product Code: | RPPB4594 |
| Size: | 10µg |
| Species: | Human |
| Target: | SCGB3A2 |
| Synonyms: | Secretoglobin, Family 3A Member 2, Uteroglobin-Related Protein 1, Pneumo Secretory Protein 1, UGRP1, PnSP-1, PNSP1, Secretoglobin Family 3A Member 2, Uteroglobin Related Protein 1, LU103, SCGB3A2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered colorless solution. |
| Formulation: | SCGB3A2 solution at a concentration of 0.4mg/ml in phosphate buffered saline (PBS) pH 8.0. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MFLINKVPLP VDKLAPLPLD NILPFMDPLK LLLKTLGISV EHLVEGLRKC VNELGPEASE AVKKLLEALS HLVGGSGGSF LINKVPLPVD KLAPLPLDNI LPFMDPLKLL LKTLGISVEH LVEGLRKCVN ELGPEASEAV KKLLEALSHL VHHHHHH |
Secretoglobin Family 3A Member 2 (SCGB3A2) is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of the SCGB3A2 gene results in susceptibility to asthma.
SCGB3A2 Human Recombinant produced in E.Coli is a non-glycosylated homodimer containing a total of 157 (2xPhe22-Val93) amino acids including a 6 aa linker and 6 aa His tag at C-terminus. The total calculated molecular mass is 17.1kDa.
| UniProt Protein Function: | Secreted cytokine-like protein (PubMed:12847263). Binds to the scavenger receptor MARCO (PubMed:12847263). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (PubMed:12847263). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed:24213919). Seems to have anti-inflammatory effects in respiratory epithelium. Also has anti-fibrotic activity in lung (PubMed:24213919). May play a role in fetal lung development and maturation (PubMed:24213919). Promotes branching morphogenesis during early stages of lung development (PubMed:24213919). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). |
| NCBI Summary: | The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma.[provided by RefSeq, Mar 2010] |
| UniProt Code: | Q96PL1 |
| NCBI GenInfo Identifier: | 16876445 |
| NCBI Gene ID: | 117156 |
| NCBI Accession: | NP_473364.1 |
| UniProt Related Accession: | Q96PL1 |
| Molecular Weight: | Molecular Mass: 7.9 kDaActual Protein Molecular Mass: 7 kDa |
| NCBI Full Name: | secretoglobin family 3A member 2 |
| NCBI Synonym Full Names: | secretoglobin family 3A member 2 |
| NCBI Official Symbol: | SCGB3A2�� |
| NCBI Official Synonym Symbols: | LU103; PNSP1; UGRP1; pnSP-1�� |
| NCBI Protein Information: | secretoglobin family 3A member 2 |
| UniProt Protein Name: | Secretoglobin family 3A member 2 |
| UniProt Synonym Protein Names: | Pneumo secretory protein 1; PnSP-1; Uteroglobin-related protein 1 |
| UniProt Gene Name: | SCGB3A2�� |
