Description
| Product Name: | Human SCGB2A2 Recombinant Protein |
| Product Code: | RPPB4592 |
| Size: | 10µg |
| Species: | Human |
| Target: | SCGB2A2 |
| Synonyms: | Mammaglobin-A, Mammaglobin-1, Secretoglobin family 2A member 2, SCGB2A2, MGB1, UGB2, MGC71974. |
| Source: | HEK293 Cells |
| Physical Appearance: | Sterile filtered lyophilized powder. |
| Formulation: | SCGB2A2 was filtered (0,4�m) and lyophilized from 0.5mg/ml in PBS buffer and 5% (w/v) Threalose�pH 7.4� |
| Solubility: | It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for 5 days. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | GSGCPLLENV ISKTINPQVS KTEYKELLQE FIDDNATTNA IDELKECFLN QTDETLSNVE VFMQLIYDSS LCDLF KLENL YFQGPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H |
The mammaglobin gene was first identified using a differential screening approach directed at the isolation of novel, human breast cancer-associated genes. Mammaglobin encodes a 10 kDa glycoprotein and is distantly relaetd to a family of epithelial secretory proteins that includes rat estramustine-binding protein/prostatein and human Clara cell 10 kDa protein (CC10)/uteroglobin. Mammaglobin, a mammary-specific member of the uterglobin family, is known to be overexpressed in human breast cancer. Studies suggest that mammaglobin is one of the first relatively mammary-specific and mammary-sensitive markers (85%). Mammaglobin may be valuable used in a panel with BRST-2 (GCDFP-15) and ER in evaluating tumors of unknown primary sites.SCGB2A2 (the mammaglobin gene) is located on chromosome 11, at locus 11q13. SCGB2A2 is member of the secretoglobin superfamily of which is a group of small dimeric secreted and sometimes glycosylated proteins. Expressed mainly in mucosa, secretoglobins appear to be involved in cell signalling, immune response, chemotaxis, and might also serve as transporters for steroid hormones in humans.
Mammaglobin-A Human Recombinant (Fc Chimera) produced in HEK cells is a single, glycosylated, polypeptide chain (Gly19-Phe93) containing a total of 321 amino acids, having a calculated molecular mass of 36.3kDa. The SCGB2A2 protein is fused to a 2 aa C-terminal linker, a 6 aa C-terminal His tag, a 7 aa TEV site and a 231 aa Human IgG1 fragment (Pro100-Lys330).
| UniProt Protein Function: | SCGB2A2: Belongs to the secretoglobin family. Lipophilin subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q13 Molecular Function:protein binding |
| UniProt Code: | Q13296 |
| NCBI GenInfo Identifier: | 2833243 |
| NCBI Gene ID: | 4250 |
| NCBI Accession: | Q13296.1 |
| UniProt Secondary Accession: | Q13296,Q86WH8, A1A522, |
| UniProt Related Accession: | Q13296 |
| Molecular Weight: | 10,122 Da |
| NCBI Full Name: | Mammaglobin-A |
| NCBI Synonym Full Names: | secretoglobin family 2A member 2 |
| NCBI Official Symbol: | SCGB2A2�� |
| NCBI Official Synonym Symbols: | MGB1; UGB2�� |
| NCBI Protein Information: | mammaglobin-A |
| UniProt Protein Name: | Mammaglobin-A |
| UniProt Synonym Protein Names: | Mammaglobin-1; Secretoglobin family 2A member 2 |
| Protein Family: | Secretoglobin family |
| UniProt Gene Name: | SCGB2A2�� |
| UniProt Entry Name: | SG2A2_HUMAN |
