Description
| Product Name: | Nanodisc Human S1PR1-Strep Protein |
| SKU: | HDFP1183 |
| Size: | 10μg |
| Target: | S1PR1 |
| Tag: | C-Flag&Strep Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1 |
| Protein Families: | GPCR, Transmembrane, Druggable Genome. |
| Protein Description: | Human S1PR1-Strep full length protein-synthetic nanodisc |
| Protein Pathways: | GPCRDB Other, S1P Signaling, Small ligand GPCRs, Angiogenesis, Angiogenesis, G-Protein Coupled Receptors Signaling Pathway. |
| Molecular Weight: | The human full length S1PR1-Strep protein has a MW of 42.8 kDa |
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
| Uniprot ID: | P21453 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
