Description
| Product Name: | Human S100A14 Recombinant Protein |
| Product Code: | RPPB4551 |
| Size: | 10µg |
| Species: | Human |
| Target: | S100A14 |
| Synonyms: | Protein S100-A14, S100 calcium-binding protein A14, S114, S100A14, S100A15, BCMP84. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The S100A14 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGQCRSANAE DAQEFSDVER AIETLIKNFH QYSVEGGKET LTPSELRDLV TQQLPHLMPS NCGLEEKIAN LGSCNDSKLE FRSFWELIGE AAKSVKLERP VRGH |
S100A14 belongs to a subfamily of proteins related by EF-hand Ca2+ binding protein superfamily. The extracellular functions of the S100 family include the ability to boost neurite outgrowth, involvement in inflammation, and motility of tumor cells. S100A14 contains 2 EF-hand Ca2+-binding domains, a myristoylation motif, a glycosylation site, and a number of potential protein kinase phosphorylation sites. S100A14 is expressed at high levels in the colon and at moderate levels in the thymus, kidney, liver, small intestine, and lung.
S100A14 Human Recombinant fused with a�20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�124 amino acids (1-104 a.a.) and having a molecular mass of 13.8kDa. The S100A14 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | S100A14: a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011] |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: cell junction; cytosol; nuclear body; perinuclear region of cytoplasm Molecular Function:chemokine receptor binding; protein binding Biological Process: defense response to bacterium; response to lipopolysaccharide; toll-like receptor 4 signaling pathway |
| NCBI Summary: | This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9HCY8 |
| NCBI GenInfo Identifier: | 20178118 |
| NCBI Gene ID: | 57402 |
| NCBI Accession: | Q9HCY8.1 |
| UniProt Secondary Accession: | Q9HCY8,Q5RHT0, |
| UniProt Related Accession: | Q9HCY8 |
| Molecular Weight: | 12kDa |
| NCBI Full Name: | Protein S100-A14 |
| NCBI Synonym Full Names: | S100 calcium binding protein A14 |
| NCBI Official Symbol: | S100A14�� |
| NCBI Official Synonym Symbols: | BCMP84; S100A15�� |
| NCBI Protein Information: | protein S100-A14 |
| UniProt Protein Name: | Protein S100-A14 |
| UniProt Synonym Protein Names: | S100 calcium-binding protein A14; S114 |
| Protein Family: | Protein |
| UniProt Gene Name: | S100A14�� |
