Description
| Product Name: | Human RSU1 Recombinant Protein |
| Product Code: | RPPB4532 |
| Size: | 20µg |
| Species: | Human |
| Target: | RSU1 |
| Synonyms: | Ras Suppressor Protein 1, Rsu-1, RSP-1, Ras Suppressor Protein 1 Variant 1, Ras Suppressor Protein 1 Variant 2, Ras Suppressor Protein 1 Variant 3, RSP1, RSU1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The RSU1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSKSLKK LVEESREKNQ PEVDMSDRGI SNMLDVNGLF TLSHITQLVL SHNKLTMVPP NIAELKNLEV LNFFNNQIEE LPTQISSLQK LKHLNLGMNR LNTLPRGFGS LPALEVLDLT YNNLSENSLP GNFFYLTTLR ALYLSDNDFE ILPPDIGKLT KLQILSLRDN DLISLPKEIG ELTQLKELHI QGNRLTVLPP ELGNLDLTGQ KQVFKAENNP WVTPIADQFQ LGVSHVFEYI RSETYKYLYG RHMQANPEPP KKNNDKSKKI SRKPLAAKNR |
RSU1 is a protein which is involved in the ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as has been established in mouse and human cell line studies. In mouse, RSU1 was originally isolated based on its ability to inhibit v-Ras transformation. RSU1 oossibly has a role in the Ras signal transduction pathway. RSU1 is also capable of suppressing v-Ras transformation in vitro.
RSU1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 300 amino acids (1-277) and having a molecular mass of 33.9 kDa.RSU1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RSU1: a leucine-rich protein that interacts with the IPP (integrin-linked kinase (ILK)/PINCH1/ parvin) focal adhesion complex. Plays a role in Ras signaling pathways. Capable of suppressing v-Ras transformation in vitro |
| UniProt Protein Details: | Protein type:Cell adhesion Chromosomal Location of Human Ortholog: 10p13 Cellular Component: focal adhesion; cytosol Molecular Function:protein binding Biological Process: Ras protein signal transduction; signal transduction; positive regulation of GTPase activity |
| NCBI Summary: | This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15404 |
| NCBI GenInfo Identifier: | 2498866 |
| NCBI Gene ID: | 6251 |
| NCBI Accession: | Q15404.3 |
| UniProt Related Accession: | Q15404 |
| Molecular Weight: | 32 kDa |
| NCBI Full Name: | Ras suppressor protein 1 |
| NCBI Synonym Full Names: | Ras suppressor protein 1 |
| NCBI Official Symbol: | RSU1�� |
| NCBI Official Synonym Symbols: | RSP-1�� |
| NCBI Protein Information: | ras suppressor protein 1 |
| UniProt Protein Name: | Ras suppressor protein 1 |
| Protein Family: | Ras suppressor protein |
| UniProt Gene Name: | RSU1�� |
| UniProt Entry Name: | RSU1_HUMAN |
