Description
| Product Name: | Human RQCD1 Recombinant Protein |
| Product Code: | RPPB4523 |
| Size: | 20µg |
| Species: | Human |
| Target: | RQCD1 |
| Synonyms: | Cell differentiation protein RCD1 homolog, Rcd-1, RQCD1, RCD1, CNOT9, CT129, RCD1+. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The RQCD1 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.1M NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MHSLATAAPV PTTLAQVDRE KIYQWINELS SPETRENALL ELSKKRESVP DLAPMLWHSF GTIAALLQEI VNIYPSINPP TLTAHQSNRV CNALALLQCV ASHPETRSAF LAAHIPLFLY PFLHTVSKTR PFEYLRLTSL GVIGALVKTD EQEVINFLLT TEIIPLCLRI MESGSELSKT VATFILQKIL LDDTGLAYIC QTYERFSHVA MILGKMVLQL SKEPSARLLK HVVRCYLRLS DNPRAREALR QCLPDQLKDT TFAQVLKDDT TTKRWLAQLV KNLQEGQVTD PRGIPLPPQ |
RQCD1 is a novel transcriptional cofactor which mediates retinoic acid-induced cell differentiation. RQCD1 down-regulates MYB- and JUN-dependent transcription and may have a role in cell differentiation. RQCD1 also has a role in retinoic acid-controlled lung development.
RQCD1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 319 amino acids (1-299 a.a.) and having a molecular mass of 35.7kDa. The RQCD1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RQCD1: Transcription factor that down-regulates MYB- and JUN- dependent transcription. May play a role in cell differentiation. Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. Belongs to the RCD1 family.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 2q35Cellular Component: CCR4-NOT complex; cytosol; membraneMolecular Function: protein binding; protein domain specific binding; protein homodimerization activityBiological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of estrogen receptor signaling pathway; negative regulation of translation; poly(A) tail shortening; sex differentiation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012] |
| UniProt Code: | Q92600 |
| NCBI GenInfo Identifier: | 74716599 |
| NCBI Gene ID: | 9125 |
| NCBI Accession: | Q92600.1 |
| UniProt Secondary Accession: | Q92600,Q96IX4, B2RPI0, B5MDQ4, B7Z1E5 |
| UniProt Related Accession: | Q92600 |
| Molecular Weight: | 29,140 Da |
| NCBI Full Name: | Cell differentiation protein RCD1 homolog |
| NCBI Synonym Full Names: | CCR4-NOT transcription complex subunit 9 |
| NCBI Official Symbol: | CNOT9�� |
| NCBI Official Synonym Symbols: | RCD1; CAF40; CT129; RCD-1; RQCD1�� |
| NCBI Protein Information: | cell differentiation protein RCD1 homolog |
| UniProt Protein Name: | Cell differentiation protein RCD1 homolog |
| UniProt Synonym Protein Names: | CCR4-NOT transcription complex subunit 9 |
| Protein Family: | Cell differentiation protein |
| UniProt Gene Name: | RQCD1�� |
| UniProt Entry Name: | RCD1_HUMAN |
