Description
| Product Name: | Human RPS18 Recombinant Protein |
| Product Code: | RPPB4518 |
| Size: | 20µg |
| Species: | Human |
| Target: | RPS18 |
| Synonyms: | Ribosomal Protein S18, D6S218E, 40S Ribosomal Protein S18,HKE3, KE-3, KE3, S18, Rhabdomyosarcoma Antigen MU-RMS-40.21, Ke-3, Ke3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | RPS18 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSLVIPE KFQHILRVLN TNIDGRRKIA FAITAIKGVG RRYAHVVLRKADIDLTKRAG ELTEDEVERV ITIMQNPRQY KIPDWFLNRQ KDVKDGKYSQ VLANGLDNKL REDLERLKKIRAHRGLRHFW GLRVRGQHTK TTGRRGRTVG VSKKK |
40S ribosomal protein S18 (RPS18) is a member of theribosomal protein S13P family. RPS18 is located in the cytoplasm. Ribosomes, theorganelles which catalyze protein synthesis, consist of a small 40S subunit anda large 60S subunit. Jointly these subunits are composedof 4 RNA species and approximately 80 structurally distinct proteins. RPS18encodes a ribosomal protein which is a component of the 40S subunit. RPS18 is arecognized binding partner of Cofilin and has been proposed to be a novelsubstrate for CaMKII. Among the diseasesassociated with RPS18 are bowen-conradi syndrome, and pasteurellosis.
RPS18 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 175 amino acids (1-152 a.a) and having a molecular mass of 20.1kDa.RPS18 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RPS18: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. Belongs to the ribosomal protein S13P family. |
| UniProt Protein Details: | Protein type:Ribosomal; Translation Chromosomal Location of Human Ortholog: 6p21.32 Cellular Component: cytosol; extracellular matrix; focal adhesion; membrane; nucleoplasm; nucleus; small ribosomal subunit Molecular Function:protein binding; RNA binding Biological Process: mRNA catabolic process, nonsense-mediated decay; ribosome biogenesis and assembly; rRNA processing; SRP-dependent cotranslational protein targeting to membrane; translation; translational initiation; viral transcription |
| NCBI Summary: | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P62269 |
| NCBI GenInfo Identifier: | 50403625 |
| NCBI Gene ID: | 6222 |
| NCBI Accession: | P62269.3 |
| UniProt Secondary Accession: | P62269,P25232, Q5SUJ3, Q6IPF8, |
| UniProt Related Accession: | P62269 |
| Molecular Weight: | 18kDa |
| NCBI Full Name: | 40S ribosomal protein S18 |
| NCBI Synonym Full Names: | ribosomal protein S18 |
| NCBI Official Symbol: | RPS18�� |
| NCBI Official Synonym Symbols: | KE3; S18; HKE3; KE-3; D6S218E�� |
| NCBI Protein Information: | 40S ribosomal protein S18 |
| UniProt Protein Name: | 40S ribosomal protein S18 |
| UniProt Synonym Protein Names: | Ke-3; Ke3; Small ribosomal subunit protein uS13 |
| Protein Family: | 40S ribosomal protein |
| UniProt Gene Name: | RPS18�� |
