Description
| Product Name: | Human RPAIN Recombinant Protein |
| Product Code: | RPPB4485 |
| Size: | 10µg |
| Species: | Human |
| Target: | RPAIN |
| Synonyms: | HRIP, RIP, RPA-interacting protein, hRIP, RPAIN. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | RPAIN protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 40% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAESLRS PRRSLYKLVG SPPWKEAFRQ RCLERMRNSR DRLLNRYRQA GSSGPGNSQN SFLVQEVMEE EWNALQSVEN CPEDLAQLEE LIDMAVLEEI QQELINQGL |
RPA-interacting protein isoform d (RPAIN) is a single-stranded-DNA binding protein which participates in various eukaryotic DNA processes such as replication, repair and recombination. RPAIN interacting protein has been indicated as an adapter protein that is involved in RPA nuclear import instead of the prototypical importin proteins that normally mediate nuclear import. RPAIN is mainly expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen.
RPAIN Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 129 amino acids (1-106 a.a.) and having a molecular mass of 14.7kDa.RPAIN is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RPAIN: Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism. 7 isoforms of the human protein are produced by alternative splicing.Protein type: DNA repair, damage; DNA replicationChromosomal Location of Human Ortholog: 17p13.2Cellular Component: nucleolus; nucleusMolecular Function: protein complex bindingBiological Process: DNA recombination; DNA repair; DNA-dependent DNA replication; protein import into nucleus |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q86UA6 |
| NCBI GenInfo Identifier: | 74727468 |
| NCBI Gene ID: | 84268 |
| NCBI Accession: | Q86UA6.1 |
| UniProt Secondary Accession: | Q86UA6,Q4G2Y0, Q4G2Y5, Q4G2Y8, Q6B4V9, Q6B4W0, Q6B4W1 Q6B4W4, B4DI36, B4DTX7 |
| UniProt Related Accession: | Q86UA6 |
| Molecular Weight: | 17,118 Da |
| NCBI Full Name: | RPA-interacting protein |
| NCBI Synonym Full Names: | RPA interacting protein |
| NCBI Official Symbol: | RPAIN�� |
| NCBI Official Synonym Symbols: | RIP; HRIP�� |
| NCBI Protein Information: | RPA-interacting protein |
| UniProt Protein Name: | RPA-interacting protein |
| UniProt Synonym Protein Names: | |
| Protein Family: | RPA-interacting protein |
| UniProt Gene Name: | RPAIN�� |
| UniProt Entry Name: | RIP_HUMAN |
