Description
| Product Name: | Human RGS19 Recombinant Protein |
| Product Code: | RPPB4452 |
| Size: | 20µg |
| Species: | Human |
| Target: | RGS19 |
| Synonyms: | GAIP, Regulator of G-protein signalling 19, G alpha interacting protein, GNAI3IP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The RGS19 protein solution (0.5mg/1ml) is formulated in Phosphate Buffered Saline (pH7.4) and 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPTPHEAEKQ ITGPEEADRP PSMSSHDTAS PAAPSRNPCC LCWCCCCSCS WNQERRRAWQ ASRESKLQPL PSCEVCATPS PEEVQSWAQS FDKLMHSPAG RSVFRAFLRT EYSEENMLFW LACEELKAEA NQHVVDEKAR LIYEDYVSIL SPKEVSLDSR VREGINKKMQ EPSAHTFDDA QLQIYTLMHR DSYPRFLSSP TYRALLLQGP SQSSSEA |
RGS19 is a member of RGS (regulator of G protein signaling) family and negatively regulates G protein coupled receptor signaling. RGS19 protein specifically cooperates with heterotrimeric GTP-binding protein G alpha i3 (GAI3).
RGS19 produced in E.Coli is a single, non-glycosylated polypeptide chain containing�237 amino acids (1-217a.a.) and having a molecular mass of 26.7kDa.RGS19 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RGS19: inhibits signal transduction by increasing the GTPase activity of g protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(I)a3 > G(I)a1 > G(O)a >> G(Z)a/G(I)a2. Activity on G(Z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. |
| UniProt Protein Details: | Protein type:GAPs, RGS; GAPs Chromosomal Location of Human Ortholog: 20q13.33 Cellular Component: beta-catenin destruction complex; cell cortex; cytoplasmic membrane-bound vesicle; cytoplasmic microtubule; Golgi apparatus; heterotrimeric G-protein complex; membrane; postsynaptic density Molecular Function:beta-catenin binding; GTPase activator activity; protein binding; protein kinase binding Biological Process: cell death; cell differentiation; dorsal/ventral axis specification; G-protein coupled receptor protein signaling pathway; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction |
| NCBI Summary: | G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49795 |
| NCBI GenInfo Identifier: | 1730186 |
| NCBI Gene ID: | 10287 |
| NCBI Accession: | P49795.1 |
| UniProt Secondary Accession: | P49795,Q53XN0, Q8TD60, A8K216, E1P5G9, |
| UniProt Related Accession: | P49795 |
| Molecular Weight: | 24,636 Da |
| NCBI Full Name: | Regulator of G-protein signaling 19 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 19 |
| NCBI Official Symbol: | RGS19�� |
| NCBI Official Synonym Symbols: | GAIP; RGSGAIP�� |
| NCBI Protein Information: | regulator of G-protein signaling 19 |
| UniProt Protein Name: | Regulator of G-protein signaling 19 |
| UniProt Synonym Protein Names: | G-alpha-interacting protein; GAIP |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS19�� |
| UniProt Entry Name: | RGS19_HUMAN |
