Description
| Product Name: | Human RGS16 Recombinant Protein |
| Product Code: | RPPB4450 |
| Size: | 10µg |
| Species: | Human |
| Target: | RGS16 |
| Synonyms: | A28-RGS14, A28-RGS14P, RGS-R, Regulator of G-protein signaling 16, RGS16, Retinally abundant regulator of G-protein signaling, Retinal-specific RGS, hRGS-r, RGSR. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear colorless solution. |
| Formulation: | The RGS16 solution (0.5mg/ml) contains Phosphate Buffered Saline (pH7.4), 0.1M NaCl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MCRTLAAFPT TCLERAKEFK TRLGIFLHKS ELGCDTGSTG KFEWGSKHSK ENRNFSEDVL GWRESFDLLL SSKNGVAAFH AFLKTEFSEE NLEFWLACEE FKKIRSATKL ASRAHQIFEE FICSEAPKEV NIDHETRELT RMNLQTATAT CFDAAQGKTR TLMEKDSYPR FLKSPAYRDL AAQASAASAT LSSCSLDEPS HT |
RGS16 is part of the ''regulator of G protein signaling'' family. RGS16 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. RGS16 Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. RGS16 regulates the kinetics of signaling in the phototransduction cascade.
RGS16 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 222 amino acids (1-202 a.a.) and having a molecular mass of 24.9 kDa. The RGS16 is fused to a 20 amino acid His Tag at N-terminal and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RGS1: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q31 Cellular Component: cytoplasm; plasma membrane Molecular Function:calmodulin binding; GTPase activator activity Biological Process: immune response; G-protein signaling, adenylate cyclase inhibiting pathway; signal transduction; positive regulation of GTPase activity |
| NCBI Summary: | This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15492 |
| NCBI GenInfo Identifier: | 115387108 |
| NCBI Gene ID: | 5996 |
| NCBI Accession: | NP_002913.3 |
| UniProt Secondary Accession: | O15492,O15492, P97428, P56700, |
| UniProt Related Accession: | Q08116 |
| Molecular Weight: | 23,858 Da |
| NCBI Full Name: | regulator of G-protein signaling 1 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 1 |
| NCBI Official Symbol: | RGS1�� |
| NCBI Official Synonym Symbols: | 1R20; BL34; IER1; IR20�� |
| NCBI Protein Information: | regulator of G-protein signaling 1; early response protein 1R20; B-cell activation protein BL34; regulator of G-protein signalling 1; immediate-early response 1, B-cell specific |
| UniProt Protein Name: | Regulator of G-protein signaling 1 |
| UniProt Synonym Protein Names: | B-cell activation protein BL34; Early response protein 1R20 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS1�� |
| UniProt Entry Name: | RGS1_HUMAN |
