Description
| Product Name: | Human REG4 Recombinant Protein |
| Product Code: | RPPB4439 |
| Size: | 10µg |
| Species: | Human |
| Target: | REG4 |
| Synonyms: | Regenerating islet-derived protein 4, Reg IV, REG-like protein, Gastrointestinal secretory protein, REG4, GISP, RELP. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | REG4 protein solution (0.25mg/ml) contains 10% glycerol & Phosphate buffered saline (pH7.4).� |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPDIIMRPS CAPGWFYHKS NCYGYFRKLR NWSDAELECQ SYGNGAHLAS ILSLKEASTIAEYISGYQRS QPIWIGLHDP QKRQQWQWID GAMYLYRSWS GKSMGGNKHC AEMSSNNNFL TWSSNECNKR QHFLCKYRPH HHHHH |
REG protein was shown to be stimulated during the regeneration of pancreatic islets. Since then, many Reg-related proteins have been identified in humans and other animals. In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated. These Reg-related proteins are classified into four subfamilies according to their amino-acid sequences, but they share a similar structure and physiological function. Reg protein is a growth factor for pancreatic beta cells and also suggests that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus. Human REG cDNA which encodes a 166-amino acid protein with a 22-amino acid signal peptide. The amino acid sequence of human REG protein has 68% homology to that of rat Reg protein.
REG4 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (23-158 a.a.) and fused to a 9 aa His Tag at C-terminus containing a total of 145 amino acids and having a molecular mass of 17kDa.REG4 shows multiple bands between 13.5-18kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | REG4: Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p13.1-p12 Cellular Component: cytoplasm; extracellular region Molecular Function:heparin binding; calcium ion binding |
| UniProt Code: | Q9BYZ8 |
| NCBI GenInfo Identifier: | 68565834 |
| NCBI Gene ID: | 83998 |
| NCBI Accession: | Q9BYZ8.1 |
| UniProt Secondary Accession: | Q9BYZ8,Q8NER6, Q8NER7, |
| UniProt Related Accession: | Q9BYZ8 |
| Molecular Weight: | 14,993 Da |
| NCBI Full Name: | Regenerating islet-derived protein 4 |
| NCBI Synonym Full Names: | regenerating islet-derived family, member 4 |
| NCBI Official Symbol: | REG4�� |
| NCBI Official Synonym Symbols: | GISP; RELP; REG-IV�� |
| NCBI Protein Information: | regenerating islet-derived protein 4; REG-4; reg IV; REG-like protein; regenerating gene type IV; gastrointestinal secretory protein; regenerating islet-derived protein IV |
| UniProt Protein Name: | Regenerating islet-derived protein 4 |
| UniProt Synonym Protein Names: | Gastrointestinal secretory protein; REG-like protein; Regenerating islet-derived protein IV; Reg IV |
| Protein Family: | Regenerating islet-derived protein |
| UniProt Gene Name: | REG4�� |
| UniProt Entry Name: | REG4_HUMAN |
