Description
| Product Name: | Human RBBP9 Recombinant Protein |
| Product Code: | RPPB4418 |
| Size: | 20µg |
| Species: | Human |
| Target: | RBBP9 |
| Synonyms: | Retinoblastoma binding protein 9, RBBP-9, Retinoblastoma-binding protein 10, RBBP-10, BOG, B5T-overexpressed gene protein, putative hydrolase RBBP9, retinoma-binding protein 9. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | RBBP9 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 100mM NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MASPSKAVIV PGNGGGDVTT HGWYGWVKKE LEKIPGFQCL AKNMPDPITA RESIWLPFME TELHCDEKTI IIGHSSGAIA AMRYAETHRV YAIVLVSAYT SDLGDENERA SGYFTRPWQW EKIKANCPYI VQFGSTDDPF LPWKEQQEVA DRLETKLHKF TDCGHFQNTE FHELITVVKS LLKVPA |
RBBP9, restricts to the nucleus and cytoplasm, is a retinoblastoma binding protein which takes part in the regulation of cell proliferation and differentiation. RBBP9 cooperates with retinoblastoma (Rb) and offers cellular resistance to the growth-inhibitory effects of TGFbeta1, therefore enabling the cellular transformation process.
RBBP9 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 206 amino acids (1-186 a.a.) and having a molecular mass of 23.1kDa.RBBP9 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RBBP9: May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1. Belongs to the RBBP9 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.-.-.-; Hydrolase Chromosomal Location of Human Ortholog: 20p11.2 Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus Molecular Function:hydrolase activity Biological Process: metabolic process; regulation of cell proliferation |
| NCBI Summary: | The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75884 |
| NCBI GenInfo Identifier: | 18202147 |
| NCBI Gene ID: | 10741 |
| NCBI Accession: | O75884.2 |
| UniProt Secondary Accession: | O75884,Q5JPH9, Q9H1D8, D3DW31, |
| UniProt Related Accession: | O75884 |
| Molecular Weight: | 186 |
| NCBI Full Name: | Putative hydrolase RBBP9 |
| NCBI Synonym Full Names: | retinoblastoma binding protein 9 |
| NCBI Official Symbol: | RBBP9�� |
| NCBI Official Synonym Symbols: | BOG; RBBP10�� |
| NCBI Protein Information: | putative hydrolase RBBP9; RBBP-9; RBBP-10; retinoma-binding protein 9; B5T overexpressed gene protein; B5T-overexpressed gene protein; retinoblastoma-binding protein 9; retinoblastoma-binding protein 10 |
| UniProt Protein Name: | Putative hydrolase RBBP9 |
| UniProt Synonym Protein Names: | B5T-overexpressed gene protein; Protein BOG; Retinoblastoma-binding protein 10; RBBP-10; Retinoblastoma-binding protein 9; RBBP-9 |
| Protein Family: | Putative hydrolase |
| UniProt Gene Name: | RBBP9�� |
| UniProt Entry Name: | RBBP9_HUMAN |
