Description
| Product Name: | Human RASSF3 Recombinant Protein |
| Product Code: | RPPB4414 |
| Size: | 20µg |
| Species: | Human |
| Target: | RASSF3 |
| Synonyms: | Ras association domain-containing protein 3, RASSF3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | RASSF3 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSSGYSS LEEDAEDFFF TARTSFFRRA PQGKPRSGQQ DVEKEKETHS YLSKEEIKEK VHKYNLAVTD KLKMTLNSNG IYTGFIKVQM ELCKPPQTSP NSGKLSPSSN GCMNTLHISS TNTVGEVIEA LLKKFLVTES PAKFALYKRC HREDQVYACK LSDREHPLYL RLVAGPRTDT LSFVLREHEI GEWEAFSLPE LQNFLRILDK EEDEQLQNLK RRYTAYRQKL EEALREVWKP D |
Ras association domain-containing protein 3 (RASSF3) is a ubiquitously expressed protein found in normal and cancerous tissues. RASSF3 is a member of RASSF family whose members contain a highly conserved Ras association domain (Ral GDS/AF-6 or RA) and function as Ras effectors/tumor suppressors. RASSF3 contains an N-terminal RA domain and a coiled-coil SARAH domain and may have 3 isoforms (RASSF3A, RASSF3B and RASSF3C) due to alternative splicing. RASSF3B and RASSF3C are shorter than RASSF3A and do not contain the RA and SARAH domain.
RASSF3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 261 amino acids (1-238a.a) and having a molecular mass of 30kDa. RASSF3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RASSF3: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 12q14.2Cellular Component: cytoplasm; plasma membraneMolecular Function: identical protein binding; protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.[supplied by OMIM, Jul 2003] |
| UniProt Code: | Q86WH2 |
| NCBI GenInfo Identifier: | 74714093 |
| NCBI Gene ID: | 283349 |
| NCBI Accession: | Q86WH2.1 |
| UniProt Secondary Accession: | Q86WH2,Q86WH1 |
| UniProt Related Accession: | Q86WH2 |
| Molecular Weight: | 10,265 Da |
| NCBI Full Name: | Ras association domain-containing protein 3 |
| NCBI Synonym Full Names: | Ras association domain family member 3 |
| NCBI Official Symbol: | RASSF3�� |
| NCBI Official Synonym Symbols: | RASSF5�� |
| NCBI Protein Information: | ras association domain-containing protein 3 |
| UniProt Protein Name: | Ras association domain-containing protein 3 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Ras association domain-containing protein |
| UniProt Gene Name: | RASSF3�� |
| UniProt Entry Name: | RASF3_HUMAN |
