Description
| Product Name: | Human RARRES1 Recombinant Protein |
| Product Code: | RPPB4407 |
| Size: | 25µg |
| Species: | Human |
| Target: | RARRES1 |
| Synonyms: | Retinoic acid receptor responder protein 1 isoform 1, TIG1, Retinoic acid receptor responder protein 1, RAR-responsive protein TIG1, RARRES1, Recombinant Human Retinoic Acid Receptor Responder 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The RARRES1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSPDDPGQP QDAGVPRRLL QQAARAALHF FNFRSGSPSA LRVLAEVQEG RAWINPKEGC KVHVVFSTER YNPESLLQEG EGRLGKCSAR VFFKNQKPRP TINVTCTRLI EKKKRQQEDY LLYKQMKQLK NPLEIVSIPD NHGHIDPSLR LIWDLAFLGS SYVMWEMTTQ VSHYYLAQLT SVRQWKTNDD TIDFDYTVLL HELSTQEIIP CRIHLVWYPG KPLKVKYHCQ ELQTPEEASG TEEGSAVVPT ELSNF |
Retinoic Acid Receptor Responder 1 (RARRES1) is a part of the TIGs family. TIGs operate like tumor suppressor genes in human cancers and are greatly expressed in skin, hair follicles and endothelial cells plus in pancreas, spleen and intestine. TIGs are growth regulators which mediate the growth suppressive effects of retinoids.
RARRES1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 275 amino acids (43-294) and having a molecular mass of 31.3 kDa. RARRES1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RARRES1: identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 3q25.32 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49788 |
| NCBI GenInfo Identifier: | 57014141 |
| NCBI Gene ID: | 5918 |
| NCBI Accession: | P49788.2 |
| UniProt Secondary Accession: | P49788,Q8N1D7 |
| UniProt Related Accession: | P49788 |
| Molecular Weight: | 25,812 Da |
| NCBI Full Name: | Retinoic acid receptor responder protein 1 |
| NCBI Synonym Full Names: | retinoic acid receptor responder 1 |
| NCBI Official Symbol: | RARRES1�� |
| NCBI Official Synonym Symbols: | LXNL; TIG1; PERG-1�� |
| NCBI Protein Information: | retinoic acid receptor responder protein 1 |
| UniProt Protein Name: | Retinoic acid receptor responder protein 1 |
| UniProt Synonym Protein Names: | Phorbol ester-induced gene 1 protein; PERG-1; RAR-responsive protein TIG1; Tazarotene-induced gene 1 protein |
| Protein Family: | Retinoic acid receptor responder protein |
| UniProt Gene Name: | RARRES1�� |
| UniProt Entry Name: | TIG1_HUMAN |
