Description
| Product Name: | Human RAB39B Recombinant Protein |
| Product Code: | RPPB4374 |
| Size: | 20µg |
| Species: | Human |
| Target: | RAB39B |
| Synonyms: | Ras-related protein Rab-39B, RAB39B, MRX72. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | RAB39B protein solution (0.25mg/ml) contains in Phosphatebuffered saline (pH7.4), 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMEAIWLY QFRLIVIGDS TVGKSCLIRR FTEGRFAQVS DPTVGVDFFSRLVEIEPGKR IKLQIWDTAG QERFRSITRA YYRNSVGGLL LFDITNRRSF QNVHEWLEET KVHVQPYQIVFVLVGHKCDL DTQRQVTRHE AEKLAAAYGM KYIETSARDA INVEKAFTDL TRDIYELVKR GEITIQEGWEGVKSGFVPNV VHSSEEVVKS ERRCLC |
RAB39B, Member RAS Oncogene Family (RAB39B) belongs to the Rab family of proteins. Rab proteins are small GTPases, which are involved in vesicular trafficking. RAB39B gene mutations are linked with X-linked mental retardation.
RAB39B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 236 amino acids (1-213 a.a) and having a molecular mass of 27kDa.RAB39B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RAB39B: May be involved in vesicular trafficking. Plays a role in synapse formation. Defects in RAB39B are the cause of mental retardation X- linked type 72 (MRX72). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRX72 patients can manifest autism spectrum disorder, seizures and macrocephaly as additional features. Belongs to the small GTPase superfamily. Rab family. |
| UniProt Protein Details: | Protein type:G protein, monomeric, Rab; G protein, monomeric; G protein Chromosomal Location of Human Ortholog: Xq28 Cellular Component: Golgi apparatus; intracellular; neuron projection; vesicle Molecular Function:myosin V binding; protein binding Biological Process: synapse organization and biogenesis; vesicle-mediated transport Disease: Mental Retardation, X-linked 72 |
| NCBI Summary: | This gene encodes a member of the Rab family of proteins. Rab proteins are small GTPases that are involved in vesicular trafficking. Mutations in this gene are associated with X-linked mental retardation. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q96DA2 |
| NCBI GenInfo Identifier: | 27734447 |
| NCBI Gene ID: | 116442 |
| NCBI Accession: | Q96DA2.1 |
| UniProt Secondary Accession: | Q96DA2,Q5JT79, Q8NEX3, |
| UniProt Related Accession: | Q96DA2 |
| Molecular Weight: | 24,622 Da |
| NCBI Full Name: | Ras-related protein Rab-39B |
| NCBI Synonym Full Names: | RAB39B, member RAS oncogene family |
| NCBI Official Symbol: | RAB39B�� |
| NCBI Official Synonym Symbols: | WSMN; MRX72�� |
| NCBI Protein Information: | ras-related protein Rab-39B |
| UniProt Protein Name: | Ras-related protein Rab-39B |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB39B�� |
| UniProt Entry Name: | RB39B_HUMAN |
