Description
| Product Name: | Human RAB23 Recombinant Protein |
| Product Code: | RPPB4353 |
| Size: | 20µg |
| Species: | Human |
| Target: | RAB23 |
| Synonyms: | RAB23 member RAS oncogene family, HSPC137, RAB family small GTP binding protein RAB 23, ras-related protein Rab-23. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The RAB23 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 0.1mM PMSF and 30% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MLEEDMEVAI KMVVVGNGAV GKSSMIQRYC KGIFTKDYKK TIGVDFLERQ IQVNDEDVRL MLWDTAGQEE FDAITKAYYR GAQACVLVFS TTDRESFEAV SSWREKVVAE VGDIPTVLVQ NKIDLLDDSC IKNEEAEALA KRLKLRFYRT SVKEDLNVNE VFKYLAEKYL QKLKQQIAED PELTHSSSNK IGVFNTSGGS HSGQNSGTLN GGDVINLRPN KQRTKKNRNP FSSC |
RAB23 belongs to the Rab family of proteins and is restricted to the cytoplasmic side of the cell membrane. RAB23 takes part in intracellular protein transportation and signal transduction facilitated by small GTPases. RAB23 is a vital negative regulator of the Sonic hedgehog signaling pathway. Alterations in the gene encoding RAB23 are the origin for Carpenter syndrome a disorder which can cause obesity, cardiac defects, polysyndactyly and craniosynostosis.
RAB23 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 254 amino acids (1-234) and having a molecular mass of 28.5 kDa.RAB23 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RAB23: Defects in RAB23 are the cause of acrocephalopolysyndactyly type 2 (ACPS2). A syndrome characterized by craniosynostosis, polysyndactyly, obesity, and cardiac defects. Belongs to the small GTPase superfamily. Rab family. |
| UniProt Protein Details: | Protein type:G protein, monomeric; G protein, monomeric, Rab; G protein Chromosomal Location of Human Ortholog: 6p11 Cellular Component: phagocytic vesicle membrane; cytoplasm; plasma membrane; endosome membrane; autophagic vacuole; phagocytic vesicle Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding Biological Process: negative regulation of proteolysis; protein transport; spinal cord dorsal/ventral patterning; cellular defense response; cilium biogenesis; embryonic digit morphogenesis; Rab protein signal transduction; negative regulation of transcription factor import into nucleus; autophagic vacuole formation; regulation of smoothened signaling pathway Disease: Carpenter Syndrome 1 |
| NCBI Summary: | This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9ULC3 |
| NCBI GenInfo Identifier: | 523425714 |
| NCBI Gene ID: | 51715 |
| NCBI Accession: | NP_001265595.1 |
| UniProt Secondary Accession: | Q9ULC3,Q68DJ6, Q8NI06, Q9P023, B2R9I5, |
| UniProt Related Accession: | Q9ULC3 |
| Molecular Weight: | 26,659 Da |
| NCBI Full Name: | ras-related protein Rab-23 |
| NCBI Synonym Full Names: | RAB23, member RAS oncogene family |
| NCBI Official Symbol: | RAB23�� |
| NCBI Official Synonym Symbols: | HSPC137�� |
| NCBI Protein Information: | ras-related protein Rab-23; RAB family small GTP binding protein RAB 23 |
| UniProt Protein Name: | Ras-related protein Rab-23 |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB23�� |
| UniProt Entry Name: | RAB23_HUMAN |
