Description
| Product Name: | Human RAB17 Recombinant Protein |
| Product Code: | RPPB5914 |
| Size: | 20µg |
| Species: | Human |
| Target: | RAB17 |
| Synonyms: | RAB17 member RAS oncogene family, ras-related protein Rab-17, FLJ12538. |
| Source: | Escherichia Coli |
| Physical Appearance: | RAB17 is supplied as a sterile filtered clear solution. |
| Formulation: | RAB17 protein 0.5mg/ml is supplied in 20mM Tris-HCL, pH-8, 0.1M NaCl, 1mM DTT and 30% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAQAHRTPQP RAAPSQPRVF KLVLLGSGSV GKSSLALRYV KNDFKSILPT VGCAFFTKVV DVGATSLKLE IWDTAGQEKY HSVCHLYFRG ANAALLVYDI TRKDSFLKAQ QWLKDLEEEL HPGEVLVMLV GNKTDLSQER EVTFQEGKEF ADSQKLLFMETSAKLNHQVS EVFNTVAQEL LQRSDEEGQA LRGDAAVALN KGPARQAKCC AH |
RAB17 is a member of the small GTPase superfamily which are found in several intracellular compartments and have a significant regulatory part in membrane trafficking. RAB17 regulates traffic through the apical recycling endosome, which indicates that RAB17 has a role in polarized arrangement in epithelial cells.
RAB17 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 232 amino acids (1-212) and having a molecular mass of 25.6 kDa.The RAB17 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RAB17: Might be involved in transcellular transport. Belongs to the small GTPase superfamily. Rab family. |
| UniProt Protein Details: | Protein type:G protein, monomeric; G protein, monomeric, Rab; G protein Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: recycling endosome; cell soma; recycling endosome membrane; basolateral plasma membrane; endocytic vesicle; apical plasma membrane; early endosome; dendrite; plasma membrane; melanosome; intracellular Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding Biological Process: filopodium formation; metabolic process; regulation of dendrite development; regulation of filopodium formation; transcytosis; endocytic recycling; melanosome transport; intracellular protein transport; regulation of synaptogenesis; regulation of endocytosis; establishment of melanosome localization; cilium biogenesis; Rab protein signal transduction; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor |
| NCBI Summary: | The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009] |
| UniProt Code: | Q9H0T7 |
| NCBI GenInfo Identifier: | 37999892 |
| NCBI Gene ID: | 64284 |
| NCBI Accession: | Q9H0T7.2 |
| UniProt Related Accession: | Q9H0T7 |
| Molecular Weight: | 23kDa |
| NCBI Full Name: | Ras-related protein Rab-17 |
| NCBI Synonym Full Names: | RAB17, member RAS oncogene family |
| NCBI Official Symbol: | RAB17�� |
| NCBI Protein Information: | ras-related protein Rab-17 |
| UniProt Protein Name: | Ras-related protein Rab-17 |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB17�� |
| UniProt Entry Name: | RAB17_HUMAN |
