Description
| Product Name: | Human PVALB Recombinant Protein |
| Product Code: | RPPB4339 |
| Size: | 25µg |
| Species: | Human |
| Target: | PVALB |
| Synonyms: | Parvalbumin alpha, PVALB, D22S749, MGC116759. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PVALB solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 50mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMSMTDL LNAEDIKKAV GAFSATDSFD HKKFFQMVGLKKKSADDVKK VFHMLDKDKS GFIEEDELGF ILKGFSPDAR DLSAKETKML MAAGDKDGDG KIGVDEFSTL VAES |
Parvalbumin alpha (PVALB) is a member of a larger group of EF hand proteins. PVALB is a high affinity calcium ion-binding protein which is structurally and functionally similar to calmodulin and troponin C. Parvalbumin is expressed in a specific population of GABAergic interneurones which are believed to have a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus.
PVALB Human Recombinant fused with a 24 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 134 amino acids (1-110 a.a.) and having a molecular mass of 14.6kDa. The PVALB is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PVA: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. Belongs to the parvalbumin family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: protein complex; cell soma; axon; cytoplasm; nucleus Molecular Function:protein homodimerization activity; protein heterodimerization activity; calcium ion binding Biological Process: cytosolic calcium ion homeostasis |
| NCBI Summary: | The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P20472 |
| NCBI GenInfo Identifier: | 131100 |
| NCBI Gene ID: | 5816 |
| NCBI Accession: | P20472.2 |
| UniProt Secondary Accession: | P20472,P78378, Q4VB78, Q5R3Q9, B2R4H7, |
| UniProt Related Accession: | P20472 |
| Molecular Weight: | 110 |
| NCBI Full Name: | Parvalbumin alpha |
| NCBI Synonym Full Names: | parvalbumin |
| NCBI Official Symbol: | PVALB�� |
| NCBI Official Synonym Symbols: | D22S749�� |
| NCBI Protein Information: | parvalbumin alpha |
| UniProt Protein Name: | Parvalbumin alpha |
| Protein Family: | Parvalbumin |
| UniProt Gene Name: | PVALB�� |
| UniProt Entry Name: | PRVA_HUMAN |
