Description
| Product Name: | Human PSMG2 Recombinant Protein |
| Product Code: | RPPB4326 |
| Size: | 10µg |
| Species: | Human |
| Target: | PSMG2 |
| Synonyms: | Proteasome assembly chaperone 2, PAC-2, Hepatocellular carcinoma-susceptibility protein 3, Tumor necrosis factor superfamily member 5-induced protein 1, PSMG2, HCCA3, PAC2, TNFSF5IP1, CLAST3, MDS003, HsT1707, MGC15092. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | PSMG2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 40% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMFVPCGE SAPDLAGFTL LMPAVSVGNV GQLAMDLIIS TLNMSKIGYF YTDCLVPMVG NNPYATTEGN STELSINAEV YSLPSRKLVA LQLRSIFIKY KSKPFCEKLL SWVKSSGCAR VIVLSSSHSY QRNDLQLRST PFRYLLTPSM QKSVQNKIKS LNWEEMEKSR CIPEIDDSEF CIRIPGGGIT KTLYDESCSK EIQMAVLLKF VSEGDNIPDA LGLVEYLNEW LQILKPLSDD PTVSASRWKI PSSWRLLFGS GLPPALF |
Proteasome assembly chaperone 2 (PSMG2) stimulates assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits and promotes compilation of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. PSMG2 is widely expressed with highest levels in the lung, brain and colon. It is moderately expressed in the muscle, stomach, spleen and heart, and weakly expressed in the small intestine, pancreas and liver. It is also highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue.
PSMG2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 287 amino acids (1-264 a.a.) and having a molecular mass of 31.8kDa.PSMG2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PSMG2: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. Belongs to the PSMG2 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 18p11.21 Cellular Component: nucleus Molecular Function:protein binding Biological Process: mitotic cell cycle spindle assembly checkpoint; proteasome assembly; negative regulation of apoptosis |
| UniProt Code: | Q969U7 |
| NCBI GenInfo Identifier: | 74731063 |
| NCBI Gene ID: | 56984 |
| NCBI Accession: | Q969U7.1 |
| UniProt Secondary Accession: | Q969U7,Q6IAH4, Q9NRV1, B0YJB3, V9GYH7, |
| UniProt Related Accession: | Q969U7 |
| Molecular Weight: | 264 |
| NCBI Full Name: | Proteasome assembly chaperone 2 |
| NCBI Synonym Full Names: | proteasome (prosome, macropain) assembly chaperone 2 |
| NCBI Official Symbol: | PSMG2�� |
| NCBI Official Synonym Symbols: | PAC2; HCCA3; CLAST3; MDS003; HsT1707; TNFSF5IP1�� |
| NCBI Protein Information: | proteasome assembly chaperone 2; PAC-2; PSMG2; HSPC260; HDCMC29P; x 003 protein; proteasome assembling chaperone 2; CD40 ligand-activated specific transcript 3; hepatocellular carcinoma susceptibility protein; hepatocellular carcinoma-susceptibility prote |
| UniProt Protein Name: | Proteasome assembly chaperone 2 |
| UniProt Synonym Protein Names: | Hepatocellular carcinoma-susceptibility protein 3; Tumor necrosis factor superfamily member 5-induced protein 1 |
| Protein Family: | Proteasome assembly chaperone |
| UniProt Gene Name: | PSMG2�� |
| UniProt Entry Name: | PSMG2_HUMAN |
