Description
| Product Name: | Human PROCR Recombinant Protein |
| Product Code: | RPPB4296 |
| Size: | 10µg |
| Species: | Human |
| Target: | PROCR |
| Synonyms: | Protein C Receptor, CD201, APC Receptor, EPCR, Centrocyclin, CCD41, CCCA. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | PROCR protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPSQDASDG LQRLHMLQIS YFRDPYHVWY QGNASLGGHL THVLEGPDTN TTIIQLQPLQ EPESWARTQS GLQSYLLQFH GLVRLVHQER TLAFPLTIRC FLGCELPPEG SRAHVFFEVA VNGSSFVSFR PERALWQADT QVTSGVVTFT LQQLNAYNRT RYELREFLED TCVQYVQKHI SAENTKGSQT SRSYTSLEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGKH HHHHH |
Protein-c Receptor (PROCR) is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The PROCR protein is an N-glycosylated type I membrane protein which enhances the activation of protein C. PROCR gene mutations are linked with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. In addition, PROCR may have a role in malarial infection and has been linked with cancer.
PROCR Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 435 amino acids (18-210a.a.) and having a molecular mass of 49.3kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). PROCR is expressed with a 242 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. |
| NCBI Summary: | The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9UNN8 |
| NCBI GenInfo Identifier: | 13626550 |
| NCBI Gene ID: | 10544 |
| NCBI Accession: | Q9UNN8.1 |
| UniProt Secondary Accession: | Q9UNN8,Q14218, Q6IB56, Q96CB3, Q9ULX1, B2RC04, |
| UniProt Related Accession: | Q9UNN8 |
| Molecular Weight: | 26,671 Da |
| NCBI Full Name: | Endothelial protein C receptor |
| NCBI Synonym Full Names: | protein C receptor |
| NCBI Official Symbol: | PROCR�� |
| NCBI Official Synonym Symbols: | CCCA; EPCR; CCD41�� |
| NCBI Protein Information: | endothelial protein C receptor |
| UniProt Protein Name: | Endothelial protein C receptor |
| UniProt Synonym Protein Names: | Activated protein C receptor; APC receptor; Endothelial cell protein C receptor; CD_antigen: CD201 |
| Protein Family: | Endothelial protein C receptor |
| UniProt Gene Name: | PROCR�� |
