Description
| Product Name: | Human PPP1R11 Recombinant Protein |
| Product Code: | RPPB4286 |
| Size: | 10µg |
| Species: | Human |
| Target: | PPP1R11 |
| Synonyms: | HCG-V, HCGV, IPP3, TCTE5, TCTEX5, Protein phosphatase 1 regulatory subunit 11, Hemochromatosis candidate gene V protein, PPP1R11. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The PPP1R11 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAEAGAG LSETVTETTV TVTTEPENRS LTIKLRKRKP EKKVEWTSDT VDNEHMGRRS SKCCCIYEKP RAFGESSTES DEEEEEGCGH THCVRGHRKG RRRATLGPTP TTPPQPPDPS QPPPGPMQH |
Protein phosphatase 1 regulatory subunit 11 (PPP1R11) is located within the major histocompatibility complex class I region on chromosome 6 and is expressed in a variety of both adult and embryonic tissues. PPP1R11 acts as an inhibitor of PP1 (protein phosphatase 1), particularly showing a sensitivity toward the metal-independent and metal-dependent forms of PP1. Deletion of a portion of the q arm of chromosome 6 is related with early onset intestinal cancer, proposing the presence of a cancer vulnerability locus.
PPP1R11 Human Recombinant produced in E. coli is a single polypeptide chain containing 149 amino acids (1-126) and having a molecular mass of 16.3 kDa. PPP1R11 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PPP1R11: Inhibitor of protein phosphatase 1.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunitChromosomal Location of Human Ortholog: 6p22.1Cellular Component: cytoplasm; nucleus; protein phosphatase type 1 complexMolecular Function: protein binding; protein phosphatase 1 binding; type 1 serine/threonine specific protein phosphatase inhibitor activityBiological Process: negative regulation of phosphoprotein phosphatase activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60927 |
| NCBI GenInfo Identifier: | 11386175 |
| NCBI Gene ID: | 6992 |
| NCBI Accession: | NP_068778.1 |
| UniProt Secondary Accession: | O60927 |
| UniProt Related Accession: | O60927 |
| Molecular Weight: | 41.3kD |
| NCBI Full Name: | protein phosphatase 1 regulatory subunit 11 |
| NCBI Synonym Full Names: | protein phosphatase 1 regulatory inhibitor subunit 11 |
| NCBI Official Symbol: | PPP1R11�� |
| NCBI Official Synonym Symbols: | HCGV; IPP3; HCG-V; TCTE5; TCTEX5; CFAP255�� |
| NCBI Protein Information: | protein phosphatase 1 regulatory subunit 11 |
| UniProt Protein Name: | Protein phosphatase 1 regulatory subunit 11 |
| UniProt Synonym Protein Names: | Hemochromatosis candidate gene V protein; HCG V; Protein phosphatase inhibitor 3 |
| Protein Family: | |
| UniProt Gene Name: | PPP1R11�� |
| UniProt Entry Name: |
