Description
| Product Name: | Human POU6F1 Recombinant Protein |
| Product Code: | RPPB4284 |
| Size: | 20µg |
| Species: | Human |
| Target: | POU6F1 |
| Synonyms: | BRN5, MPOU, TCFB1, Brain-5, Brn-5, mPOU homeobox protein, Brain-specific homeobox/POU domain protein 5. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The POU5F1 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMPGISSQ ILTNAQGQVI GTLPWVVNSA SVAAPAPAQS LQVQAVTPQL LLNAQGQVIA TLASSPLPPP VAVRKPSTPE SPAKSEVQPI QPTPTVPQPA VVIASPAPAA KPSASAPIPI TCSETPTVSQ LVSKPHTPSL DEDGINLEEI REFAKNFKIR RLSLGLTQTQ VGQALTATEG PAYSQSAICR FEKLDITPKS AQKLKPVLEK WLNEAELRNQ EGQQNLMEFV GGEPSKKRKR RTSFTPQAIE ALNAYFEKNP LPTGQEITEI AKELNYDREV VRVWFCNRRQ TLKNTSKLNV FQIP |
POU6F1 is a member of the POU transcription factor family. POU6F1 is transcription factor that binds favorably to a variant of the octamer motif (5'-ATGATAAT-3'). POU6F1 is exclusively expressed in the embryo in the developing brain, however in the adult its expression is confined to the brain, heart, skeletal muscle and lung. In the brain, the highest expression levels are found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum.
POU6F1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 324 amino acids (1-301 a.a.) and having a molecular mass of 35kDa.POU6F1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | POU6F1: Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3'). Belongs to the POU transcription factor family. Class- 6 subfamily. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: nucleoplasm; nucleus; actin cytoskeleton Molecular Function:DNA binding; transcription factor activity Biological Process: muscle development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; heart development; brain development |
| UniProt Code: | Q14863 |
| NCBI GenInfo Identifier: | 2495306 |
| NCBI Gene ID: | 5463 |
| NCBI Accession: | Q14863.1 |
| UniProt Secondary Accession: | Q14863,Q15944, Q6DK47, Q7Z7P6, |
| UniProt Related Accession: | Q14863 |
| Molecular Weight: | 301 |
| NCBI Full Name: | POU domain, class 6, transcription factor 1 |
| NCBI Synonym Full Names: | POU class 6 homeobox 1 |
| NCBI Official Symbol: | POU6F1�� |
| NCBI Official Synonym Symbols: | BRN5; MPOU; TCFB1�� |
| NCBI Protein Information: | POU domain, class 6, transcription factor 1; brn-5; brain-5; mPOU homeobox protein; brain-specific homeobox/POU domain protein 5 |
| UniProt Protein Name: | POU domain, class 6, transcription factor 1 |
| UniProt Synonym Protein Names: | Brain-specific homeobox/POU domain protein 5; Brain-5; Brn-5; mPOU homeobox protein |
| Protein Family: | POU domain, class 6, transcription factor |
| UniProt Gene Name: | POU6F1�� |
| UniProt Entry Name: | PO6F1_HUMAN |
