Description
| Product Name: | Human POLR2K Recombinant Protein |
| Product Code: | RPPB4276 |
| Size: | 10µg |
| Species: | Human |
| Target: | POLR2K |
| Synonyms: | Polymerase (RNA) II (DNA Directed) Polypeptide K, 7.0kDa, RNA Polymerases I, II, And III Subunit ABC4, DNA-Directed RNA Polymerase II Subunit K, RNA Polymerase II 7.0 KDa Subunit, ABC10-Alpha, RPB10alpha, RPB7.0, RPB12,DNA Directed RNA Polymerases I, II, And III 7.0 Kda Polypeptide, DNA-Directed RNA Polymerases I, II, And III Subunit RPABC4, Polymerase (RNA) II (DNA Directed) Polypeptide K (7.0kD), HsRPB10a, HRPB7.0, RPABC4, POLR2K. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | POLR2K protein solution (0. 5mg/ml) containing Phosphatebuffered saline (pH7.4), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDTQKDV QPPKQQPMIY ICGECHTENE IKSRDPIRCR ECGYRIMYKK RTKRLVVFDA R |
Polymerase (RNA) II (DNA directed) Polypeptide K, also known� as POLR2K is am ember of the archaealRpoP/eukaryotic RPC10 RNA polymerase subunit family. POLR2K is one of thesmallest subunits of RNA polymerase II, the polymerase is responsible for synthesizingmessenger RNA in eukaryotes. In addition, the other two DNA-directed RNApolymerases share this subunit.�
POLR2K Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 81 amino acids (1-58 a.a) and having a molecular mass of 9.4kDa.POLR2K is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | POLR2K: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. |
| UniProt Protein Details: | Protein type:DNA repair, damage; RNA processing Chromosomal Location of Human Ortholog: 8q22.2 Cellular Component: cytosol; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase III complex; nucleoplasm; nucleus Molecular Function:zinc ion binding Biological Process: fibroblast growth factor receptor signaling pathway; gene expression; mRNA capping; nuclear mRNA splicing, via spliceosome; positive regulation of gene expression, epigenetic; positive regulation of interferon type I production; positive regulation of viral transcription; regulation of transcription from RNA polymerase I promoter; RNA elongation from RNA polymerase I promoter; RNA elongation from RNA polymerase II promoter; RNA-mediated gene silencing; snRNA transcription from RNA polymerase II promoter; somatic stem cell maintenance; termination of RNA polymerase I transcription; transcription from RNA polymerase II promoter; transcription from RNA polymerase III promoter; transcription initiation from RNA polymerase I promoter; transcription initiation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair |
| NCBI Summary: | This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P53803 |
| NCBI GenInfo Identifier: | 4826924 |
| NCBI Gene ID: | 5440 |
| NCBI Accession: | NP_005025.1 |
| UniProt Secondary Accession: | P53803,Q6IBD4, |
| UniProt Related Accession: | P53803 |
| Molecular Weight: | 7,004 Da |
| NCBI Full Name: | DNA-directed RNA polymerases I, II, and III subunit RPABC4 |
| NCBI Synonym Full Names: | RNA polymerase II subunit K |
| NCBI Official Symbol: | POLR2K�� |
| NCBI Official Synonym Symbols: | RPB12; RPABC4; RPB7.0; hRPB7.0; hsRPB10a; RPB10alpha; ABC10-alpha�� |
| NCBI Protein Information: | DNA-directed RNA polymerases I, II, and III subunit RPABC4 |
| UniProt Protein Name: | DNA-directed RNA polymerases I, II, and III subunit RPABC4 |
| UniProt Synonym Protein Names: | ABC10-alpha; DNA-directed RNA polymerase II subunit K; RNA polymerase II 7.0 kDa subunit; RPB7.0; RPB10alpha |
| UniProt Gene Name: | POLR2K�� |
