Description
| Product Name: | Human PFN4 Recombinant Protein |
| Product Code: | RPPB4236 |
| Size: | 25µg |
| Species: | Human |
| Target: | PFN4 |
| Synonyms: | PFN-4, Profilin-IV, Profilin4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | PFN4 Human solution containing 20mM Trsi HCL pH-8, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSHLQSLLLD TLLGTKHVDS AALIKIQERS LCVASPGFNV TPSDVRTLVN GFAKNPLQAR REGLYFKGKD YRCVRADEYS LYAKNENTGV VVVKTHLYLL VATYTEGMYP SICVEATESL GDYLRKKGS |
PFN4 is a small actin-binding protein that participates in the dynamic turnover and restructuring of the actin cytoskeleton. PFN4 is localized in all eukaryotic organisms in the majority of cells. PFN4 is crucial for spatially and temporally controlled growth of actin microfilaments, which is a necessary process in cellular locomotion and cell shape changes.
PFN4 Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 149 amino acids (1-129 a.a.) and having a molecular mass of 16.4 kDa. PFN4 protein is fused to a 20 amino acid His tag at N-terminus and purified by standard chromatography.
| UniProt Protein Function: | profilin 4: Binds to actin and affects the structure of the cytoskeleton. Belongs to the profilin family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: cytoskeleton; cytoplasm Molecular Function:lipid binding |
| UniProt Code: | Q8NHR9 |
| NCBI GenInfo Identifier: | 20810490 |
| NCBI Gene ID: | 375189 |
| NCBI Accession: | AAH29523.1 |
| UniProt Secondary Accession: | Q8NHR9,Q53TL9, |
| UniProt Related Accession: | Q8NHR9 |
| Molecular Weight: | 14,319 Da |
| NCBI Full Name: | Profilin family, member 4 |
| NCBI Synonym Full Names: | profilin family, member 4 |
| NCBI Official Symbol: | PFN4�� |
| NCBI Protein Information: | profilin-4; profilin IV |
| UniProt Protein Name: | Profilin-4 |
| UniProt Synonym Protein Names: | Profilin IV |
| UniProt Gene Name: | PFN4�� |
| UniProt Entry Name: | PROF4_HUMAN |
