Description
| Product Name: | Human PF4V1 Recombinant Protein |
| Product Code: | RPPB1240 |
| Size: | 10µg |
| Species: | Human |
| Target: | PF4V1 |
| Synonyms: | PF4V1, Platelet Factor 4 Variant 1, CXCL4L1, CXCL4V1, PF4alt, PF4var1, SCYB4V1, PF4-ALT, PF4A, C-X-C Motif Chemokine 4, Platelet Factor 4 Variant, Platelet Factor 4, Variant 1 (PF4-Like) , C-X-C Motif Chemokine 4 Variant. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless clear solution. |
| Formulation: | PF4V1 protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSFARAEAE EDGDLQCLCV KTTSQVRPRH ITSLEVIKAG PHCPTAQLIA TLKNGRKICL DLQALLYKKI IKEHLES |
Platelet Factor 4 Variant 1 (PF4V1) is a member of the intercrine alpha (chemokine CxC) family. PF4V1 is an inhibitor of angiogenesis and inhibitor of endothelial cell chemotaxis (in vitro).�
PF4V1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 97 amino acids (31-104 a.a.) and having a molecular mass of 10.6kDa.PF4V1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PF4V1: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro). Belongs to the intercrine alpha (chemokine CxC) family. |
| UniProt Protein Details: | Protein type:Chemokine; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 4q12-q21 Cellular Component: extracellular space Molecular Function:chemokine activity; CXCR chemokine receptor binding; heparin binding Biological Process: G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; positive regulation of leukocyte chemotaxis; regulation of cell proliferation; response to lipopolysaccharide |
| NCBI Summary: | The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015] |
| UniProt Code: | P10720 |
| NCBI GenInfo Identifier: | 130306 |
| NCBI Gene ID: | 5197 |
| NCBI Accession: | P10720.1 |
| UniProt Secondary Accession: | P10720,A1L4S0, |
| UniProt Related Accession: | P10720 |
| Molecular Weight: | 11,553 Da |
| NCBI Full Name: | Platelet factor 4 variant |
| NCBI Synonym Full Names: | platelet factor 4 variant 1 |
| NCBI Official Symbol: | PF4V1�� |
| NCBI Official Synonym Symbols: | PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1�� |
| NCBI Protein Information: | platelet factor 4 variant |
| UniProt Protein Name: | Platelet factor 4 variant |
| UniProt Synonym Protein Names: | C-X-C motif chemokine 4 variant; CXCL4L1; PF4alt; PF4var1 |
| Protein Family: | Platelet factor |
| UniProt Gene Name: | PF4V1�� |
| UniProt Entry Name: | PF4V_HUMAN |
